Trial reportJapanese journal of ophthalmology2026
A prospective, randomized study comparing the effects of preservative-free latanoprost and preserved latanoprost eyedrops on MMP-9 expression and ocular surface disease index in glaucoma patients.
Trial report in Japanese journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
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Abstract
purposeTo investigate the effect of preservative-containing and preservative-free latanoprost eyedrops on dry eye symptoms and matrix metalloproteinase 9 expression in untreated open-angle glaucoma patients. STUDY
designProspective
methodsTreatment-naïve open-angle glaucoma patients were randomly assigned to either preservative-containing or preservative-free latanoprost groups. The ocular surface disease index score, Schirmer test, tear break up time, corneal staining score, and matrix metalloproteinase 9 expression in tears were prospectively compared before and at 1 and 3 months after drug instillation.
resultsOcular surface disease index score, Schirmer's test, tear break up time, corneal staining score, and matrix metalloproteinase 9 expression levels did not significantly differ between the two groups before drug instillation. After 3 months, the preservative-free latanoprost group exhibited a significantly longer tear break up time and improved corneal staining score. The proportion of patients with positive matrix metalloproteinase 9 in tears was lower in the preservative-free group, although this difference was not statistically significant (75.0% vs. 62.5%, P = 0.118).
conclusionCompared with preservative-containing latanoprost, the preservative-free preparation led to improved tear break up time and a potential reduction in positive matrix metalloproteinase 9 expression after 3 months in untreated open-angle glaucoma patients.
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