ArticleMikrochimica acta2026
Encapsulating gold nanoclusters into zinc-glutamate metal organic frameworks for ferric ions detection in zebrafish embryos.
Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gold nanoclusters (AuNCs), ultrasmall aggregates of gold atoms with unique molecular-like electronic structures and excellent photoluminescent properties, have emerged as promising candidates for fluorescence-based bioanalytical applications. However, the fluorescence intensity of AuNCs is relatively low, which significantly restricts their practical applications in high sensitivity fluorescence detection and imaging. This study successfully designed a fluorescent probe by encapsulating AuNCs in zinc-glutamate metal organic frameworks (ZG-MOF). Notably, the fluorescence intensity of the encapsulated AuNCs was significantly enhanced by nearly one-third owing to the confined pore size of ZG-MOF. This probe exhibits high specificity for ferric ions recognition with a rapid response. Furthermore, it shows an excellent linear correlation with ferric ions concentrations in the range 5.0–1000.0 µM. Moreover, the probe has been successfully applied to real-time fluorescence imaging of ferric ions in zebrafish embryos, and can monitor ferroptosis in zebrafish embryos induced by exogenous agents, achieving in vivo visualization of ferric ions distribution.
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