Evidence map›Paper›PMID 41739155›Full record

ArticleJournal of gastroenterology2026

Clinicopathological features of localized-type IgG4-related cholecystitis: a nationwide multicenter study in Japan.

Itaru Naitoh, Takahiro Nakazawa, Kenji Notohara, Dai Inoue, Takahiro Komori, Yujiro Kawakami, Masaki Kuwatani, Tsukasa Ikeura, Takanori Sano, Kazuro Chiba and 11 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

21 authors.

Itaru NaitohDepartment of Gastroenterology, Nagoya City University Midori Municipal Hospital, 1-77 Shiomigaoka, Midori-Ku, Nagoya, 458-0037, Japan. inaito@med.nagoya-cu.ac.jp.ORCID 0000-0001-8342-886X
Takahiro NakazawaDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Kenji NotoharaDepartment of Anatomic Pathology, Kurashiki Central Hospital, Kurashiki, Okayama, Japan.
Dai InoueDepartment of Radiology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
Takahiro KomoriDepartment of Radiology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
Yujiro KawakamiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
Masaki KuwataniDepartment of Gastroenterology and Hepatology, Hokkaido University Hospital, Sapporo, Japan.
Tsukasa IkeuraDivision of Gastroenterology and Hepatology, Third Department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
Takanori SanoDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kazuro ChibaDepartment of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
Hiroyuki MatsubayashiDivision of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
Takuya IshikawaDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Atsushi KannoDivision of Gastroenterology, Department of Medicine, Jichi Medical University, Tochigi, Japan.
Atsuhiro MasudaDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Masahiro ShiokawaDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ami HosoiDepartment of Internal, Medicine Isesaki Municipal Hospital, Isesaki, Japan.
Masaomi IchinokawaDepartment of Surgery, Obihiro Kosei Hospital, Obihiro, Japan.
Fumihiro OkumuraDepartment of Gastroenterology, Gifu Prefectural Tajimi Hospital, Tajimi, Japan.
Mitsuhiro KawanoDepartment of Hematology & Immunology, Kanazawa Medical University, Ishikawa, Japan.
Terumi KamisawaDivision of Gastroenterology and Center of IgG4-Related Disease, Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
Atsushi MasamuneDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Funding

Ministry of Health, Labour and Welfare 23FC1015
6 · The paper itself

Abstract

backgroundImmunoglobulin G4 (IgG4)-related cholecystitis represents gallbladder involvement in IgG4-related disease (IgG4-RD). However, localized-type IgG4-related cholecystitis is rare and remains poorly characterized. We conducted a nationwide, multicenter study to clarify the clinicopathological features of localized-type IgG4-related cholecystitis in Japan.

methodsWe collected clinical information, imaging data, and tissue slides from suspected cases of IgG4-related cholecystitis for central review, and evaluated their clinicopathological features.

resultsFifteen patients were diagnosed with localized-type IgG4-related cholecystitis. The incidence of localized-type IgG4-related cholecystitis was 0.59% (15/2560) among all IgG4-related gastroenterological diseases across 30 institutions. The median age was 62 years (range, 54-70 years), and 10 patients were men. Elevated serum IgG4 levels and other IgG4-RD lesions were observed in all 15 patients. Imaging findings demonstrated subepithelial lesions (SELs) of the gallbladder in all patients, and cystic lesions within SELs suggestive of adenomyomatosis (ADM) in nine patients. Among the 11 patients with available histopathological analyses, two distinct types of mass-forming lesions (inflammatory pseudotumors) characterized by storiform fibrosis and obliterative phlebitis were identified: ADM-type in six cases and mural hypertrophy-type in three cases. Eleven patients underwent surgery and four received glucocorticoids therapy. Within 2-4 weeks of initiating glucocorticoid therapy, complete resolution was achieved in one patient, and partial improvement in three patients.

conclusionLocalized-type IgG4-related cholecystitis is characterized by imaging findings of SELs. It shares histopathological features of IgG4-RD, and often has unique lesions centered around ADM. It responds to glucocorticoid therapy.

Indexed as

CholecystitisImmunoglobulin GImmunoglobulin G4-Related DiseaseAgedFemaleHumansJapanMaleMiddle AgedRetrospective StudiesImmunoglobulin GAdenomyomatosisAutoimmune pancreatitisIgG4-related cholecystitisIgG4-related diseaseInflammatory pseudotumor

Identifiers

PMID41739155

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.