Evidence map›Paper›PMID 41739147›Full record

ArticleDiabetologia2026

The diabetes-associated K

Jordyn R Dobson, Prasanna K Dadi, Matthew T Dickerson, Arya Y Nakhe, Soma Behera, Shannon E Gibson, Spencer J Peachee, Anthony Piron, Miriam Cnop, David A Jacobson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jordyn R DobsonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0009-0007-1815-1279
Prasanna K DadiDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5377-5991
Matthew T DickersonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-6187-3951
Arya Y NakheDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-2192-5865
Soma BeheraDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0009-0006-7171-3050
Shannon E GibsonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0009-0001-3596-469X
Spencer J PeacheeDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0009-0004-6147-0046
Anthony PironULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.ORCID http://orcid.org/0000-0002-7931-3784
Miriam CnopULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.ORCID http://orcid.org/0000-0002-5112-1692
David A JacobsonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA. david.a.jacobson@vanderbilt.edu.ORCID http://orcid.org/0000-0003-1816-5375

Funding

Molecular Mechanisms Regulating Pancreatic Delta Cell Function and DysfunctionR01DK129340 · NIDDK · VANDERBILT UNIVERSITY · PI David Aaron Jacobson · 2022 to 2026
$2.3M
Secretagogue and Gi/o-GPCR signaling through the islet Na+/K+-ATPase in health and diabetesR01DK136768 · NIDDK · VANDERBILT UNIVERSITY · PI David Aaron Jacobson · 2023 to 2026
$2.0M
Calcium Extrusion in the Context of Pancreatic Islet Function and DysfunctionR01DK144192 · NIDDK · VANDERBILT UNIVERSITY · PI David Aaron Jacobson · 2025 to 2026
$1.3M
Division of Diabetes, Endocrinology, and Metabolic Diseases 5T32DK07563Division of Diabetes, Endocrinology, and Metabolic Diseases DK097392Division of Diabetes, Endocrinology, and Metabolic Diseases DK129340Division of Diabetes, Endocrinology, and Metabolic Diseases DK129340-S1Division of Diabetes, Endocrinology, and Metabolic Diseases DK136768Horizon 2020 Framework Programme 667191Leona M. and Harry B. Helmsley Charitable Trust G-1912-03550NIDDK NIH HHS R01 DK129340NIDDK NIH HHS R01 DK136768NIDDK NIH HHS R01 DK144192NIGMS NIH HHS 1T32GM139800-01
6 · The paper itself

Abstract

aims/hypothesisThe two-pore domain K

methodsLocalisation of TALK-2 was evaluated with immunofluorescent staining as well as TALK-2-GFP construct co-expressed with intracellular markers. TALK-2 function was evaluated by measuring changes in cytoplasmic Ca

resultsTALK-2 protein localised to the plasma membrane and ER membrane, and formed functional channels on the ER membrane. Ca CONCLUSIONS/

interpretationThese data support the notion that TALK-2 functions on the human beta cell ER membrane to increase the electrical driving force for beta cell Ca

Indexed as

CalciumEndoplasmic ReticulumGlucoseInsulinInsulin-Secreting CellsPotassium Channels, Tandem Pore DomainDiabetes Mellitus, Type 2HumansInsulin SecretionCalciumGlucoseInsulinPotassium Channels, Tandem Pore DomainBeta cellCa2+ERInsulin secretionIon channelsIsletK2PLive cell imagingSingle nucleotide polymorphismsType 2 diabetes

Identifiers

PMID41739147
PMCPMC13109171

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.