Evidence map›Paper›PMID 41739081›Full record

ArticleAIDS (London, England)2026

N-acetyl-aspartyl-glutamate connects neuroinflammatory signatures to attention and working memory in people with HIV.

Leah H Rubin, Atiksh Chandra, Jesse Alt, Raha M Dastgheyb, Hayley Romero, Jennifer M Coughlin, Rana Rais, Rebecca T Veenhuis, Barbara S Slusher

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Leah H RubinDepartment of Neurology.
Atiksh ChandraDepartment of Neurology.
Jesse AltJohns Hopkins Drug Discovery; Johns Hopkins University School of Medicine, Baltimore, MD.
Raha M DastgheybDepartment of Neurology.
Hayley RomeroDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine.
Jennifer M CoughlinDepartment of Psychiatry and Behavioral Sciences.
Rana RaisDepartment of Neurology.
Rebecca T VeenhuisDepartment of Neurology.
Barbara S SlusherDepartment of Neurology.

Funding

Therapeutic CoreP30MH075673 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Leah Helane Rubin · 2006 to 2026
$33.2M
Immune dynamics shaping blood brain barrier integrity in virally suppressed people with HIVR01MH125300 · NIMH · JOHNS HOPKINS UNIVERSITY · PI COUGHLIN, JENNIFER MARIE, RUBIN, LEAH HELANE · 2020 to 2024
$3.5M
NIMH NIH HHS P30 MH075673NIMH NIH HHS R01 MH125300
6 · The paper itself

Abstract

Despite viral suppression, many people with HIV (PWH) experience persistent cognitive difficulties. We previously demonstrated that cerebrospinal fluid (CSF) N-acetyl-aspartyl-glutamate (NAAG) was associated with spatial attention and working memory. Here, we report that CSF NAAG also correlates with an inflammatory signature (M-CSF, IL-15, MCP-1, sCD40L, IL-18, MMP-9) that relates to spatial attention and working memory. These results suggest that CSF NAAG may serve as an immunomodulatory biomarker relevant to cognition in PWH.

Indexed as

AttentionCerebrospinal FluidDipeptidesHIV InfectionsMemory, Short-TermNeuroinflammatory DiseasesAdultBiomarkersCytokinesFemaleHumansMaleBiomarkersCytokinesDipeptidesisospaglumic acid

Identifiers

PMID41739081
PMCPMC13181819

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.