Evidence map›Paper›PMID 41738766›Full record

ArticleChronic obstructive pulmonary diseases (Miami, Fla.)2026

Isoflavone Intake is Associated With Decreased Chronic Obstructive Pulmonary Disease Morbidity.

Daniel C Belz, Ernesto Quiroz, Han Woo, Mariah K Jackson, Nirupama Putcha, Ashraf Fawzy, Wendy Lorizio, Corrine K Hanson, Nadia N Hansel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chronic obstructive pulmonary diseases (Miami, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniel C BelzDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Ernesto QuirozDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Han WooDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Mariah K JacksonMedical Nutrition Program, College of Allied Health Professions, University of Nebraska, Omaha, Nebraska, United States.
Nirupama PutchaDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Ashraf FawzyDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Wendy LorizioDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Corrine K HansonMedical Nutrition Program, College of Allied Health Professions, University of Nebraska, Omaha, Nebraska, United States.
Nadia N HanselDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.

Funding

The Environmental Assessments Core (FSC)P50MD010431 · NIMHD · JOHNS HOPKINS UNIVERSITY · PI MATSUI, ELIZABETH C. · 2015 to 2019
$3.5M
NIH/National Institute on Minority Health and Health Disparities P50MD010431U.S. Environmental Protection Agency 83615001
6 · The paper itself

Abstract

Introduction: Isoflavones, phenolic compounds in legumes and soy products, are linked to reduced risk of chronic diseases such as coronary heart disease. However, effects on respiratory diseases like chronic obstructive pulmonary disease (COPD) are understudied. Methods: Former smokers with COPD were enrolled in a prospective cohort study. Morbidity was assessed at baseline, 3, and 6 months using the COPD Assessment Test (CAT), Clinical COPD Questionnaire (CCQ), modified Medical Research Council (mMRC), St George’s Respiratory Questionnaire (SGRQ), Ease of Cough and Sputum Clearance (ECSC), and exacerbation history. Spirometry and biomarkers of platelet activation, inflammation, and oxidative stress were obtained. Dietary intake was assessed via a food frequency questionnaire, with total isoflavone intake calculated as the sum of genistein, daidzein, glycitein, formononetin, and biochanin A. Associations were analyzed with generalized estimating equation regression analysis and adjusted for baseline covariates. Results: A total of 99 participants (mean age 66.4, 55% female, 41% White, and a baseline forced expiratory volume in 1 second percentage predicted of 49.8%) had a mean isoflavone intake of 1.8mg (standard deviation [SD]=3.1). One SD increase in total isoflavone intake was associated with lower CAT (β=–2.0, Conclusion: Increased isoflavone intake was associated with improved respiratory morbidity and reduced platelet activation, suggesting a potential dietary pathway influencing COPD morbidity.

Indexed as

chronic obstructive pulmonary diseasedietFood Frequency Questionnaireisoflavonesrespiratory morbidity

Identifiers

PMID41738766
PMCPMC13142288

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.