Evidence map›Paper›PMID 41738765›Full record

ArticlemBio2026

Novel

Sade Pratt, Donelly A van Schalkwyk, Lindsay Stewart, Emma Filtenborg Hocke, Samirah Mannan, Charlotte Berry, Julian Muwanguzi-Karugaba, Debbie Nolder, Claire Rogers, Peter L Chiodini and 7 more

Abstract read
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sade PrattDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Donelly A van SchalkwykDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, United Kingdom.ORCID 0000-0002-7375-3439
Lindsay StewartDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Emma Filtenborg HockeDepartment of Immunology and Microbiology, Centre for Translational Medicine and Parasitology, University of Copenhagen, Copenhagen, Denmark.
Samirah MannanDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Charlotte BerryDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Julian Muwanguzi-KarugabaDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Debbie NolderUK Health Security Agency Malaria Reference Laboratory, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Claire RogersDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Peter L ChiodiniUK Health Security Agency Malaria Reference Laboratory, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Ryan C HenriciPerelman School of Medicine Center for Global Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Sophie MossDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Nina BillowsDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Jody PhelanDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, United Kingdom.ORCID 0000-0001-8323-7019
Taane G ClarkDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, United Kingdom.ORCID 0000-0001-8985-9265
Susana CampinoDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Colin J SutherlandDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, United Kingdom.ORCID 0000-0003-1592-6407

Funding

BBSRC BB/X018156/1Medical Research Council MR/T016124/1MRC MR/R020973/1MRC MR/X005895/1
6 · The paper itself

Abstract

Recent evidence indicates that the clinical efficacy of the antimalarial combination artemether-lumefantrine may be compromised by emerging IMPORTANCE: In our studies of UK travelers returning from Africa with malaria, we have encountered a small number of cases where standard combination drugs have failed to completely clear the infection. In this study, we present new assessments of the effectiveness of the major drugs in use against such parasites and link these findings to the genetic profiles of the parasites causing each infection. We identify new genetic types in some of these patient samples that may provide new markers for monitoring malaria drug resistance in African communities.

Indexed as

AntimalarialsArtemisininsDrug ResistanceGenotypeLumefantrinePlasmodium falciparumProtozoan ProteinsHumansMalaria, FalciparumUgandaUnited KingdomAntimalarialsartemisininArtemisininsLumefantrineProtozoan Proteinsantimalarial agentsartemisinin combination therapydrug resistance mechanismsdrug susceptibility testing

Identifiers

PMID41738765
PMCPMC13059730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.