Evidence map›Paper›PMID 41738749›Full record

ArticleMicrobiology spectrum2026

EsxN drives ISG15-mediated dsDNA release to activate cGAS-STING signaling and promote mycobacterial survival.

Qiao Zhang, Abulimiti Abudukadier, Haiqi Chen, Luyan Xiong, Peibo Li, Zhen Gong, Jianping Xie

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qiao ZhangState Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Institute of Modern Biopharmaceuticals, Southwest University, Chongqing, China.ORCID 0000-0003-1199-4912
Abulimiti AbudukadierState Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Institute of Modern Biopharmaceuticals, Southwest University, Chongqing, China.ORCID 0009-0005-3763-1716
Haiqi ChenState Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Institute of Modern Biopharmaceuticals, Southwest University, Chongqing, China.
Luyan XiongState Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Institute of Modern Biopharmaceuticals, Southwest University, Chongqing, China.
Peibo LiChongqing Public Health Medical Center, Chongqing, China.
Zhen GongDepartment of Clinical Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.ORCID 0000-0001-8141-1087
Jianping XieState Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Institute of Modern Biopharmaceuticals, Southwest University, Chongqing, China.ORCID 0000-0002-8959-8146

Funding

Chongqing Public Health Key Specialty (Discipline) Construction ProjectNational Natural Science Foundation of China 82302534National Natural Science Foundation of China 82472325, 82211530059Natural Science Foundation of Chongqing CSTB2024NSCQ-MSX0703Scientific Research Foundation of the Education Department of Anhui Province of China 2022AH050730
6 · The paper itself

Abstract

Tuberculosis, caused by

Indexed as

Antigens, BacterialBacterial ProteinsCytokinesDNAMembrane ProteinsMycobacterium tuberculosisNucleotidyltransferasesUbiquitinscGAS-STING Signaling PathwayCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHost-Pathogen InteractionsHumansImmunity, InnateInnate Immunity RecognitionMacrophagesMicrobial ViabilityAntigens, BacterialBacterial ProteinscGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseCytokinesDNAISG15 protein, humanMembrane ProteinsNucleotidyltransferasesSTING1 protein, humanSTING ProteinUbiquitinscGAS-STINGEsxNISG15Mycobacteriumtype I interferon

Identifiers

PMID41738749
PMCPMC13055286

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.