ArticleEuropean journal of neurology2026
Brain Abscesses Complicating Bacterial Meningitis-A Nationwide Cohort Study From the Netherlands.
Article in European journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBrain abscesses rarely complicate bacterial meningitis while their clinical characteristics and outcomes have not been systematically assessed. We studied prevalence, pathogen distribution, clinical characteristics including treatment, and outcomes of brain abscess in bacterial meningitis patients.
methodsIn a prospective Dutch national cohort of community-acquired bacterial meningitis (January 2006 to October 2023), we identified patients with a brain abscess diagnosed by the treating physician. Presence of abscesses was confirmed by re-evaluation of the cranial imaging.
resultsOf the 2918 episodes included, 56 were complicated by a brain abscess (prevalence 1.9%, 95% confidence interval [CI] 1.5-2.5). For Streptococcus pneumoniae the prevalence of abscesses among meningitis episodes was 1.1% (95% CI 0.7%-1.6%) while it was 3.6% (95% CI 2.6%-5.0%) for other bacteria. Prevalence was highest in meningitis caused by the Streptococcus anginosus group (11/21, 52.4%), Klebsiella pneumoniae (1/10, 10.0%), Listeria monocytogenes (8/175, 4.6%), Escherichia coli (1/22, 4.5%), and group A streptococcus (3/79, 3.8%). Prevalence increased between 2006-2014 and 2015-2023, with a ratio of 1.8 (95% CI 1.7-2.1). In meningitis patients with abscesses, 14-day survival was 94% and 40 of 56 (71%) patients had an unfavourable outcome. In 9 of 56 (16%) patients the abscess was treated with a neurosurgical intervention (extra-ventricular CSF drain or abscess aspiration). All received prolonged antibiotic treatment.
conclusionsMost brain abscesses among meningitis patients were caused by pneumococci, but non-pneumococcal streptococci had the highest risk for abscesses. Patients with abscesses had a high risk for an unfavourable outcome.
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