ArticleJournal of the National Cancer Center2026
Clinicopathologic, genetic and immune cell infiltration analysis of colorectal signet ring cell carcinoma with comparison to conventional adenocarcinoma.
Article in Journal of the National Cancer Center, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The impact of uterine position during brachytherapy on treatment outcomes and toxicity in patients with cervical cancer.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
- MYC in Oncogenesis and Therapeutic Implications.MedComm · 2026Review
- Distinct genomic landscape of colorectal signet ring cell carcinoma reveals frequent KMT2 family alterations and SMAD4 inactivation.BMC cancer · 2026Article
- Article
- Physical activity and exercise in cervical cancer: a state-of-the-art review.Cancer causes & control : CCC · 2026Review
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Authors and funding
12 authors.
Funding
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Abstract
Objective: We sought to characterize the genomic and immune landscape of signet ring cell carcinoma (SRCC), a rare and aggressive subtype of colorectal cancer (CRC). Methods: Tissue samples and clinicopathological data were retrospectively analyzed from 37 SRCC and 172 conventional adenocarcinomas (AC) of rectum and sigmoid colon. The genetic and immune profiles were assessed using DNA next-generation sequencing (NGS) and multiplex immunohistochemistry. Results: Compared to AC, SRCC patients were younger, had higher tumor, node, metastasis (TNM) stages and tumor grades (all Conclusions: Colorectal SRCC is a clinically and molecularly distinct and highly malignant subtype compared to AC. It exhibits a "pseudo-T cell-inflamed" tumor microenvironment with increased total CD8
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