ArticleFrontiers in neurology
The effect of levodopa on speech graphs in non-demented patients with multiple system atrophy and Parkinson's disease.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: An objective topological analysis for any arbitrary network was provided by graph theory, which was implemented to reveal topological properties of brain networks in a wide range of neurodegenerative diseases. Objectives: To investigate the difference of the topology of speech graphs among parkinsonian-type multiple system atrophy patients (MSA-P), idiopathic Parkinson's disease (PD) patients, and healthy controls (HC). To explore the effect of levodopa on the topology of speech graphs in MSA-P and PD patients. Methods: We applied a graph analysis of topology of speech graphs in MSA-P patients ( Results: MSA-P patients mentioned more about their memory and remaining time than PD patients ( Conclusion: MSA-P patients' speech graphs were denser and smaller than both PD patients and healthy adults. The graph analysis of semantic fluency can differentiate MSA-P from PD to some extent. Importantly, in MSA-P patients, the impaired speech topology can be partially restored by levodopa.
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