Evidence map›Paper›PMID 41737981›Full record

ArticleJournal of vascular diseases2025

Sexual Dimorphism in Abdominal Aortic Aneurysm-Insights from Clinical and Experimental Studies.

Zain Husain Islam, Hongzhang Mei, Zoe Tetz, Rohan Kanchetty, Sophia Stanisic, Nicholas Hoyt, William Aaron Marcum, Campbell Johnston, Eric William Kent, Mengxue Zhang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of vascular diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zain Husain IslamDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0002-0641-228X
Hongzhang MeiDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60603, USA.ORCID 0000-0003-0242-7035
Zoe TetzDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0009-0004-7853-6443
Rohan KanchettyDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Sophia StanisicDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Nicholas HoytDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
William Aaron MarcumDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0009-0001-0673-7324
Campbell JohnstonDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0009-0001-8011-7086
Eric William KentDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Mengxue ZhangDepartment of Pathology, The University of Chicago Medicine, Chicago, IL 60637, USA.
Nina IslamDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Alvin AnandDepartment of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60603, USA.ORCID 0009-0008-7493-4865
Kaijie ZhangDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Li YinDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.
Bowen WangDepartment of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA.

Funding

The Role of Amino Acid Starvation Response Kinase GCN2 in Abdominal Aortic AneurysmR01HL162895 · NHLBI · UNIVERSITY OF VIRGINIA · PI Bowen Wang · 2022 to 2026
$2.0M
NHLBI NIH HHS R01 HL162895
6 · The paper itself

Abstract

Abdominal aortic aneurysm (AAA) is a prevalent vascular disease with high mortality rates upon rupture. AAA features a distinct sexual dimorphism, with a prevalence three times higher in males than in females. Interestingly, females are faced with a greater risk of rupture and a worse prognosis following surgical repairs. Nevertheless, stratified approaches for managing and predicting outcomes of AAA in male and female patients remain limited, largely hindered by our incomplete understanding of the mechanisms underlying this sex dimorphism. In this article, we will summarize the recent clinical and preclinical efforts aimed at understanding the therapeutic and mechanistic implications of sex-specific factors shaping AAA.

Indexed as

abdominal aortic aneurysmperipheral vascular diseasesexual dimorphism

Identifiers

PMID41737981
PMCPMC12927653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.