Evidence map›Paper›PMID 41737911›Full record

ArticleKidney diseases (Basel, Switzerland)

Estimated Glomerular Filtration Rate Slope Predicts Survival and Renal Outcomes in Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis: Development and Validation of a Pathogen-Free Model.

Jiahui Wang, Weiwei Kong, Junni Wang, Anqi Ni, Xiaohan Huang, Liangliang Chen, Meifang Wang, Yanhong Ma, Pingping Ren, Jianghua Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney diseases (Basel, Switzerland). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jiahui WangKidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Institute of Nephrology, Zhejiang University, Zhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, China.
Weiwei KongKidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Institute of Nephrology, Zhejiang University, Zhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, China.
Junni WangKidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Institute of Nephrology, Zhejiang University, Zhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, China.
Anqi NiKidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Institute of Nephrology, Zhejiang University, Zhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, China.
Xiaohan HuangKidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Institute of Nephrology, Zhejiang University, Zhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, China.
Liangliang ChenKidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Institute of Nephrology, Zhejiang University, Zhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, China.
Meifang WangKidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Institute of Nephrology, Zhejiang University, Zhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, China.
Yanhong MaKidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Institute of Nephrology, Zhejiang University, Zhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, China.
Pingping RenKidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Institute of Nephrology, Zhejiang University, Zhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, China.
Jianghua ChenKidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Institute of Nephrology, Zhejiang University, Zhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, China.
Fei HanKidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Institute of Nephrology, Zhejiang University, Zhejiang Clinical Research Center of Kidney and Urinary System Disease, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study explores the potential of estimated glomerular filtration rate (eGFR) slope as a noninvasive marker for predicting renal survival and patient survival in myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody-associated glomerulonephritis (AAGN). Methods: A total of 377 MPO-AAGN patients were included. Kaplan-Meier and Cox regression analyses were performed to assess the predictive value of eGFR slopes for renal survival and patient survival. Then, the models were validated by discrimination, calibration, and decision curve analysis. Results: The eGFR slope (calculated using a linear mixed-effects model with baseline and follow-up eGFR values up to defined timepoints), higher with better renal recovery, had a median of 2.54 (IQR: 0.49-6.02) mL/min/1.73 m Conclusion: eGFR slopes are valuable predictors of renal and patients' survival in MPO-AAGN, providing valuable prognostic information that could enhance risk stratification and clinical decision-making.

Indexed as

Antineutrophil cytoplasmic antibody-associated vasculitisEstimated glomerular filtration rate slopeKidney failurePredictive modelSurvival

Identifiers

PMID41737911
PMCPMC12928716

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.