Evidence map›Paper›PMID 41737884›Full record

ArticleNeural plasticity2026

Functional Changes in the Glymphatic System in Children With Sensorineural Hearing Loss: A Study of Diffusion Tensor Imaging.

Jin Wang, Jiayan Zhuang, Kongqing Li, Gengbiao Zhang, Hongyi Zheng, Wenbin Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural plasticity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jin WangDepartment of Medical Imaging, Second Affiliated Hospital of Shantou University Medical College, Shantou, China, st120.cn.ORCID 0009-0009-4691-4709
Jiayan ZhuangDepartment of Radiology, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, China.ORCID 0000-0002-9394-8401
Kongqing LiDepartment of Medical Imaging, Second Affiliated Hospital of Shantou University Medical College, Shantou, China, st120.cn.ORCID 0009-0008-0826-3709
Gengbiao ZhangDepartment of Medical Imaging, Second Affiliated Hospital of Shantou University Medical College, Shantou, China, st120.cn.ORCID 0000-0002-4044-3776
Hongyi ZhengDepartment of Medical Imaging, Second Affiliated Hospital of Shantou University Medical College, Shantou, China, st120.cn.ORCID 0000-0003-2378-5261
Wenbin ZhengDepartment of Medical Imaging, Second Affiliated Hospital of Shantou University Medical College, Shantou, China, st120.cn.ORCID 0000-0002-1750-4999

Funding

Basic and Applied Basic Research Foundation of Guangdong ProvinceNatural Science Foundation of Guangdong ProvinceSpecial Fund Project for Science and Technology Innovation Strategy of Guangdong Province
6 · The paper itself

Abstract

Aim: Diffusion tensor imaging-analysis along the perivascular space (DTI-ALPS) indicators and free-water (FW) mapping derived from diffusion tensor imaging (DTI) data have been proposed as noninvasive markers of glymphatic system (GS) function. This study aimed to investigate GS function in children with sensorineural hearing loss (SNHL) with particular focus on the sensitive period of auditory development. Methods: This study enrolled 53 children with SNHL (SNHL group) and 42 age- and sex-matched healthy children (healthy control [HC] group). Based on the age of 36 months, we separated the study participants into two groups: Group A (0-36 months; A-SNHL group, Results: Compared to the HC group, the ALPS index for both hemispheres in the SNHL group was significantly lower (L: Conclusion: Children with SNHL (especially those over 3 years old) might exhibit compromised cerebral glymphatic function, possibly attributable to clearance dysfunction and interstitial fluid (ISF) retention. Despite the recognized limitation of DTI-ALPS, its integration with FW mapping may enhance the noninvasive indirect evaluation of glymphatic function.

Indexed as

Diffusion Tensor ImagingGlymphatic SystemHearing Loss, SensorineuralChildChild, PreschoolFemaleHumansInfantInfant, NewbornMalediffusion tensor imagingfree-water mappingglymphatic systemmagnetic resonance imagingsensorineural hearing loss

Identifiers

PMID41737884
PMCPMC12927958

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.