Evidence map›Paper›PMID 41737883›Full record

ArticleACS catalysis2025

Substrate Analogs Implicate a Free Radical Pathway in Tyrosine Hydroxylase Catalysis.

Ephrahime S Traore, Yifan Wang, Wendell P Griffith, Aimin Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS catalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ephrahime S TraoreDepartment of Chemistry, University of Texas at San Antonio, San Antonio, Texas 78249, United States.ORCID 0000-0001-6419-9248
Yifan WangDepartment of Chemistry, University of Texas at San Antonio, San Antonio, Texas 78249, United States; Department of Chemistry, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0003-0378-2469
Wendell P GriffithDepartment of Chemistry, University of Texas at San Antonio, San Antonio, Texas 78249, United States.ORCID 0000-0003-2633-6103
Aimin LiuDepartment of Chemistry, University of Texas at San Antonio, San Antonio, Texas 78249, United States.ORCID 0000-0002-4182-8176

Funding

RCMI Center for Interdiscplinary Health Research CIHRG12MD007591 · NIMHD · UNIVERSITY OF TEXAS SAN ANTONIO · PI PERRY, GEORGE · 2012 to 2016
$10.4M
Heme-dependent chemistry in tyrosine oxidation: Diversity Supplement on 5R01GM108988-08 for supporting Samuel MontoyaR01GM108988 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI LIU, AIMIN · 2014 to 2025
$4.2M
Contribution of Ligand Sets to Oxygen Activation in Iron-dependent BiocatalystsR35GM147510 · NIGMS · UNIVERSITY OF GEORGIA · PI Yifan Wang · 2022 to 2026
$1.9M
Structure-Function Relationship study of HupZF31GM145187 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI TRAORE, EPHRAHIME · 2022 to 2024
$117k
NIGMS NIH HHS F31 GM145187NIGMS NIH HHS R01 GM108988NIGMS NIH HHS R35 GM147510NIMHD NIH HHS G12 MD007591
6 · The paper itself

Abstract

Heme-dependent tyrosine hydroxylases (TyrH) are critical enzymes in catecholamine biosynthesis, yet the role of the substrate's

Indexed as

Electron paramagnetic resonanceEnzyme kineticsHemeIntermediateOxygenationRadical spin-trapResonance RamanX-ray crystallography

Identifiers

PMID41737883
PMCPMC12928749

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.