ArticleCase reports in cardiology2026
Persistent Hiccups as an Atypical Sole Manifestation of ST-Segment Elevation Myocardial Infarction: An Interesting Case Report.
Article in Case reports in cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Persistent Hiccups as an Atypical Sole Manifestation of ST-Segment Elevation Myocardial Infarction: An Interesting Case Report.Case reports in cardiology · 2026Article
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14 authors.
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Abstract
Background: Myocardial infarction (MI) commonly presents with chest pain, dyspnea, diaphoresis, and nausea; however, atypical and nonclassical presentations are increasingly recognized and may delay diagnosis and management. Persistent hiccups as the sole presenting manifestation of ST-elevation myocardial infarction (STEMI) are exceedingly rare, with only a few cases reported. Awareness of such unusual presentations is essential to avoid missed or delayed diagnoses. Case Presentation: A 60-year-old male presented to the outpatient clinic with a 1-month history of persistent hiccups without chest pain or other associated symptoms. He had no significant past medical history, cardiovascular risk factors, or prior medication use. Physical examination and vital signs were within normal limits. Laboratory evaluation revealed markedly elevated cardiac troponin levels (20 ng/mL), whereas creatine kinase, AST, lactate dehydrogenase, and B-type natriuretic peptide levels were within normal ranges. Electrocardiography showed normal sinus rhythm with ST-segment elevation and deep Discussion: The proposed mechanism of hiccups in inferior wall MI involves irritation of the phrenic or vagus nerves due to ischemia or inflammation near the diaphragm, particularly in RCA territory infarctions. Review of previously reported cases demonstrates a consistent association between persistent hiccups and inferior wall ischemia, most often related to RCA occlusion. This case reinforces the need to consider cardiac etiologies in patients with unexplained or refractory hiccups, even in the absence of classical ischemic symptoms. Conclusion: Persistent hiccups may represent a rare but important atypical presentation of inferior wall STEMI. Early cardiac evaluation, including electrocardiography and cardiac biomarkers, should be considered in such cases to enable timely diagnosis and intervention, potentially improving patient outcomes.
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