ArticleFrontiers in molecular biosciences2026
Cuproptosis-related gene signatures define immune subtypes and predict prognosis in gastric cancer.
Article in Frontiers in molecular biosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Harnessing Cuproptosis for Antitumor Immunity: A Review of Current Evidence and Therapeutic Strategies.Molecular carcinogenesis · 2026Review
- Integrative multi-omics reveals the POSTNFrontiers in immunology · 2026Article
- Cancer-associated fibroblasts as architects of acquired immune-privileged-like niches in gastrointestinal cancers: lessons from ocular immune privilege and barrier biology.Frontiers in immunology · 2026Review
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Introduction: Despite recent improvements in diagnostic and therapeutic strategies, gastric cancer (GC) continues to be a major contributor to global cancer fatalities, resulting in suboptimal patient prognosis overall. Cuproptosis, defined as a regulated death mode initiated by intracellular copper overload, has not been comprehensively examined in the context of the tumor immune microenvironment or its prognostic relevance in stomach adenocarcinoma. Methods: Comprehensive transcriptomic analyses of TCGA and GEO cohorts were performed to identify cuproptosis-related molecular subtypes and to develop a prognostic risk model based on cuproptosis-associated genes. Correlations between the risk score and features of the TIME were thoroughly evaluated. RT-qPCR was conducted in 14 paired gastric tumor and adjacent normal tissues to validate the expression of key prognostic genes. Results: Three distinct cuproptosis-associated molecular subtypes were identified in STAD. A five-gene prognostic signature- Conclusion: The identified cuproptosis-related gene signature is associated with the immunological heterogeneity of gastric cancer. Together, these results point to previously unrecognized links between cuproptosis and antitumor immunity, may provide insights for refining immunotherapeutic strategies in gastric cancer. Continued experimental investigation will be necessary to unravel how cuproptosis contributes to gastric cancer development and to validate its association with immune regulation.
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