Evidence map›Paper›PMID 41737756›Full record

ArticleJDS communications2026

Characterization of extracellular vesicles at parturition in dairy cows with late-gestation heat stress.

L T Casarotto, H N Jones, L Galio, C Henry, P Chavatte-Palmer, G E Dahl

Abstract read
In one paragraph

Article in JDS communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Placental adaptation to maternal environment in domestic animals.The Journal of reproduction and development · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

L T CasarottoDepartment of Animal Sciences, University of Florida, Gainesville, FL 32611.
H N JonesDepartment of Physiology and Aging, University of Florida College of Medicine, Gainesville, FL 32611.
L GalioUniversité Paris-Saclay, UVSQ, INRAE, BREED, Jouy-en-Josas, France, 78350.
C HenryUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, PAPPSO, Jouy-en-Josas, France, 78350.
P Chavatte-PalmerUniversité Paris-Saclay, UVSQ, INRAE, BREED, Jouy-en-Josas, France, 78350.
G E DahlDepartment of Animal Sciences, University of Florida, Gainesville, FL 32611.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EV) are recognized as important mediators of cell-cell communication, capable of transferring various cargo between cells. Thus, EV are potential biomarkers of health status in heat-stressed cows. We hypothesized that heat stress during late gestation would alter the protein profile of EV at parturition in dairy cows. To test this, maternal plasma samples were collected within 2 h after parturition (n = 16-17/treatment) from cows exposed to late-gestation heat stress (HT) or an active cooling system (CL). The EV were isolated from plasma via single-step size exclusion chromatography. Preparations were checked for quality by transmission electronic microscopy and then quantified by nanoparticle tracking analysis before proteomic analysis. High-resolution MS was performed, and a two-sided, unpaired Welch's t-test was done on proteins showing at least 3 valid values in one group and at least 70% of valid values in the other group using log2 (label-free quantification intensity). The significance threshold was

Identifiers

PMID41737756
PMCPMC12926086

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.