Evidence map›Paper›PMID 41737699›Full record

ReviewClinical kidney journal2026

Transformative global models for CKD care: case studies and strategies.

James O Burton, Andrew H Frankel, Katherine Kwon, María Marqués, Gengru Jiang, Jiguang Wang, Kieran McCafferty

Abstract readReview
In one paragraph

Review in Clinical kidney journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

James O BurtonDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0003-1176-7592
Andrew H FrankelDepartment of Renal Medicine, Imperial College Healthcare NHS Trust, London, UK.
Katherine KwonClinical Affairs, Panoramic Health, AZ, USA.
María MarquésPuerta de Hierro University Hospital, Madrid, Spain.ORCID https://orcid.org/0000-0001-9691-2546
Gengru JiangXinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jiguang WangRui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0001-8511-1524
Kieran McCaffertyDepartment of Renal Medicine, Barts Health NHS Trust, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease (CKD) affects approximately 10% of adults worldwide and is associated with an elevated risk of cardiovascular disease, such as heart failure, and increased prevalence of comorbidities such as type 2 diabetes. Early CKD diagnosis and intervention are crucial to prevent progression to advanced kidney disease, which imposes a significant clinical and economic burden on health systems and patients alike. Despite the availability of global CKD management guidelines, adherence remains low, particularly with respect to the use of sodium-glucose cotransporter 2 inhibitors (SGLT2is), which offer strong cardiorenal benefits particularly when initiated in a timely manner. This gap underscores the urgent need for practical solutions to translate existing guideline recommendations into improved clinical practice across the CKD management pathway, encompassing screening, treatment initiation and referral. This manuscript highlights successful global initiatives in CKD management, presenting a 'call-to-action' to support healthcare systems and providers in achieving improved CKD management worldwide. By bringing together eight diverse 'Champions of Change' initiatives from various health systems, this paper presents innovative and transformative solutions across the entire CKD management pathway, from early diagnosis to treatment. These case studies underscore the potential of tailored, context-specific strategies for transforming CKD care. By adopting core principles such as proactive screening, risk stratification strategies, multidisciplinary collaboration, knowledge-sharing and patient-centred approaches, healthcare systems and providers can adapt these successful models to their local settings, thereby advancing global efforts to prevent CKD progression and improve patient outcomes.

Indexed as

best practicechronic kidney disease (CKD)guideline-directed medical therapy (GDMT)managementsodium-glucose cotransporter 2 (SGLT2) inhibitors

Identifiers

PMID41737699
PMCPMC12926661

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.