ArticleBioactive materials2026
Scaffold-mediated miRNA-155 inhibition promotes regenerative macrophage polarisation leading to anti-inflammatory, angiogenic and neurogenic responses for wound healing.
Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Application of 3D-Bioprinting in Treatment of Chronic Wounds: A Review.Life (Basel, Switzerland) · 2026Review
- Immunogenicity and Integration of a Decellularized Extracellular Matrix-Based Scaffold for the Reconstruction of Human Foreskin: A Preclinical Animal Study.Bioengineering (Basel, Switzerland) · 2025Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic wounds represent a significant clinical challenge due to persistent inflammation and impaired nerve regeneration that delay healing. Conventional treatments often yield inconsistent and limited success. Combinatorial strategies that integrate biomaterial scaffolds with gene delivery offer a promising approach to promote tissue repair. MicroRNAs (miRNAs), particularly miRNA-155, are key regulators of wound healing. miRNA-155 is highly expressed in inflammatory conditions and modulates macrophage activation, polarisation, and nerve regeneration. In this context, this study introduces a miRNA-155 inhibitor-activated scaffold designed to modulate the chronic wound environment by inhibiting miRNA-155. miRNA-155 inhibitor complexed GET nanoparticles were incorporated into collagen-glycosaminoglycan (CG) scaffolds. Scaffold-mediated miRNA-155 inhibition in both non-polarised (M0) and pro-inflammatory (M1) macrophages promoted anti-inflammatory (M2) polarisation, confirmed by molecular and protein analysis. The regenerative potential of this macrophage polarisation was validated through inflammatory and angiogenic functional assays with endothelial cells. In parallel, scaffold-mediated miRNA-155 inhibition in dorsal root ganglia (DRG) enhanced axonal regrowth, essential for the synergistic repair of chronic wounds across the skin-nerve axis.
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Registered trials
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