Evidence map›Paper›PMID 41737604›Full record

ArticleOpen life sciences2026

Computational approaches for the identification of potential HDAC2 inhibitors and histamine H3 receptor antagonists from

Tarique Sarwar, Hajed Obaid A Alharbi, Fahad A Alhumaydhi, Rashid Mumtaz Khan, Arshad Husain Rahmani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tarique SarwarDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia.
Hajed Obaid A AlharbiDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia.ORCID https://orcid.org/0000-0003-4566-2932
Fahad A AlhumaydhiDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia.ORCID https://orcid.org/0000-0002-0151-8309
Rashid Mumtaz KhanDepartment of Chemistry, College of Sciences, Qassim University, Buraydah 51452, Saudi Arabia.
Arshad Husain RahmaniDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) encompasses early emerging deficits in repetitive sensory-motor behaviors and social communication. Rooted in a solid genetic foundation, ASD exhibits diversity among individuals but consistently manifests core features in restricted repetitive behaviors and social communication. ASD originates from early neural reorganization and alterations in brain development, forming a spectrum from mild to severe. The economic burden of ASD is substantial, driven by the ongoing need for assistance in adulthood. Histone deacetylase (HDAC) modulation, including HDAC2, influences ASD traits. Interest in HDAC modulation has led to the FDA approval of drugs that show promise. Additionally, studies suggest histamine, a CNS neurotransmitter, and H3R antagonism may impact social behavior in ASD. Recognizing the significance of HDAC2 and H3R, we conducted virtual screening of phytocompounds from

Indexed as

autism spectrum disorderBerberis vulgariscinnamyl acetateH3RHDAC2molecular dynamics simulation

Identifiers

PMID41737604
PMCPMC12927461

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.