Evidence map›Paper›PMID 41737541›Full record

ArticleJHEP reports : innovation in hepatology2026

HCC recurrence in liver transplants treated with hypothermic oxygenated machine perfusion: An international matched cohort study.

Janina Eden, Philip C Müller, Christoph Kuemmerli, Marco Bongini, Francesca Albanesi, Carlo Sposito, Gabriela Berlakovich, Bettina M Buchholz, Florin Botea, Stefania Camagni and 37 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHEP reports : innovation in hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05520320 (Assessment of Long-term Outcomes After Transplantation of Donor Livers Preserved by Hypothermic Oxygenated Machine Perfusion), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05520320 completednot on this map

Assessment of Long-term Outcomes After Transplantation of Donor Livers Preserved by Hypothermic Oxygenated Machine Perfusion (HOPE): a Retrospective Cohort Analysis of Real-world Data (IDEAL-D Stage 4)

TypeobservationalSponsorUniversity Medical Center GroningenRan2022 to 2023Enrolled1,202ConditionsOrgan Preservation, Liver Transplantation, Hypothermic Machine PerfusionArmsHypothermic oxygenated machine perfusion (any device)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors.

Janina EdenDepartment of Surgery, Section of HPB Surgery and Liver Transplantation, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.
Philip C MüllerDepartment of Visceral Surgery, University of Basel, Clarunis, Basel, Switzerland.
Christoph KuemmerliDepartment of Visceral Surgery, University of Basel, Clarunis, Basel, Switzerland.
Marco BonginiInstituto Nazionale Tumori IRCCS Milano, University of Milan, Italy.
Francesca AlbanesiInstituto Nazionale Tumori IRCCS Milano, University of Milan, Italy.
Carlo SpositoInstituto Nazionale Tumori IRCCS Milano, University of Milan, Italy.
Gabriela BerlakovichDivision of Transplantation, Medical University of Vienna, Vienna, Austria.
Bettina M BuchholzDepartment of Visceral Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Florin BoteaFundeni Clinical Institute, Center of General Surgery and Liver Transplantation; "Titu Maiorescu" University, Bucharest, Romania.
Stefania CamagniDepartment of Organ Failure and Transplantation, ASST Papa Giovanni XXIII, Bergamo, Italy.
Matteo CesconDepartment of General Surgery and Transplantation, IRCCS Azienda Ospedaliero-Univeritaria of Bologna, University of Bologna, Bologna, Italy.
Umberto CilloChirurgia Generale 2, Hepato-Biliary-Pancreatic Unit and Liver Transplant Center, Padova University Hospital, Padova, Italy.
Fabio ColliGeneral Surgery 2U, Liver Transplant Centre, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.
Philippe CompagnonDepartment of Transplant Surgery, University of Geneva, Geneva, Switzerland.
Luciano G De CarlisDepartment of General Surgery and Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Riccardo De CarlisDepartment of General Surgery and Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Fabrizio Di BenedettoHepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy.
Jule DingfelderDivision of Transplantation, Medical University of Vienna, Vienna, Austria.
Dulce DiogoAdult Liver Transplantation Unit, Department of Surgery and Gastroenterology, Coimbra Hospital and University Center, Coimbra, Portugal.
Daniele DondossolaGeneral and Liver Transplant Surgery Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, and Department of Pathophysiology and Transplantation Università degli Studi di Milano, Milan, Italy.
Moritz DrefsDepartment of Transplant Surgery, University of Munich Grosshaderm, Germany.
Jiri FronekTransplant Surgery Department, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic.
Giuliana GerminarioDepartment of General Surgery and Transplantation, IRCCS Azienda Ospedaliero-Univeritaria of Bologna, University of Bologna, Bologna, Italy.
Enrico GringeriChirurgia Generale 2, Hepato-Biliary-Pancreatic Unit and Liver Transplant Center, Padova University Hospital, Padova, Italy.
Christiano GuidettiHepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy.
Georg GyöriDivision of Transplantation, Medical University of Vienna, Vienna, Austria.
Matej KocikTransplant Surgery Department, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic.
Efrayim H KüçükerbilErasmus MC Transplant Institute, University Medical Center Rotterdam, Division of HPB and Transplant Surgery, Rotterdam, the Netherlands.
Dionysios KoliogiannisDepartment of Transplant Surgery, University of Munich Grosshaderm, Germany.
Hwai-Ding LamDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Georg LurjeDepartment of Surgery, Universitätsklinikum Heidelberg, Heidelberg, Germany.
Paolo MagistriHepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy.
Diethard MonbaliuDepartment of Abdominal Transplantation, Leuven Transplant Center, University Hospitals Leuven, Leuven, Belgium.
Mostafa El MoumniDepartment of Surgery, Section of Epidemiology and Statistics, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.
Beat P MüllerDepartment of Visceral Surgery, University of Basel, Clarunis, Basel, Switzerland.
Damiano PatronoGeneral Surgery 2U, Liver Transplant Centre, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.
Wojciech G PolakErasmus MC Transplant Institute, University Medical Center Rotterdam, Division of HPB and Transplant Surgery, Rotterdam, the Netherlands.
Robert J PorteDepartment of Surgery, Section of HPB Surgery and Liver Transplantation, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.
Matteo RavaioliDepartment of General Surgery and Transplantation, IRCCS Azienda Ospedaliero-Univeritaria of Bologna, University of Bologna, Bologna, Italy.
Michel RayarCHU Rennes, Service de Chirurgie Hépatobiliaire et Digestive, Rennes, France.
Renato RomagnoliGeneral Surgery 2U, Liver Transplant Centre, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.
Gustaf SörensenTransplant Institute, Sahlgrenska University Hospital, Gothenburg, Sweden.
Deniz UlukDepartment of Surgery, Universitätsklinikum Heidelberg, Heidelberg, Germany.
Pierre A ClavienSwiss HPB and Transplant Center, Department of Visceral Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland.
Vincenzo MazzaferroInstituto Nazionale Tumori IRCCS Milano, University of Milan, Italy.
Philipp DutkowskiDepartment of Visceral Surgery, University of Basel, Clarunis, Basel, Switzerland.
Vincent E de MeijerDepartment of Surgery, Section of HPB Surgery and Liver Transplantation, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background & Aims: Liver transplantation (LT) for hepatocellular carcinoma (HCC) is performed worldwide, with 5-year survival rates of approximately 70%. However, post-transplant HCC recurrence occurs in 15-20% of recipients. We aimed to evaluate, for the first time, long-term recurrence-free survival in a large international cohort of patients undergoing LT for HCC using grafts treated with hypothermic oxygenated machine perfusion (HOPE). Methods: This observational Results: The overall HCC recurrence rate in the HOPE-REAL cohort was 6.9% (41/599), with no significant difference between DBD and DCD liver transplants (7.1% [25/350] Conclusions: HCC recurrence was rare after transplantation of livers treated with HOPE. Long-term survival in HOPE-treated HCC recipients was significantly better than in those receiving non-perfused livers, and comparable to outcomes in non-HCC recipients. These findings warrant validation in a randomized clinical trial. Impact and implications: This Clinical trial number: NCT05520320.

Indexed as

HCC recurrenceHepatocellular carcinomaHOPEhypothermic oxygenated machine perfusionischemia reperfusion injuryliver transplantation

Identifiers

PMID41737541
PMCPMC12926642

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Registered trials

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