Evidence map›Paper›PMID 41737528›Full record

ArticleComplex psychiatry

Systematic Review of Methylenetetrahydrofolate Reductase (

Juliana Brum Moraes, Carlos Eduardo Coral Oliveira, Daniela Frizon Alfieri, Luísa Manfredin Vila, Nicoly Justino Euzébio, Edna Maria Vissoci Reiche, Sandra Odebrecht Vargas Nunes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Complex psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Behavioral sciences (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Juliana Brum MoraesHealth Sciences Post-Graduation Program, Health Sciences Centre, State University of Londrina, Londrina, Brazil.
Carlos Eduardo Coral OliveiraSchool of Medicine, Pontifical Catholic University of Paraná, Londrina, Brazil.
Daniela Frizon AlfieriHealth Sciences Post-Graduation Program, Health Sciences Centre, State University of Londrina, Londrina, Brazil.
Luísa Manfredin VilaHealth Sciences Post-Graduation Program, Health Sciences Centre, State University of Londrina, Londrina, Brazil.
Nicoly Justino EuzébioHealth Sciences Post-Graduation Program, Health Sciences Centre, State University of Londrina, Londrina, Brazil.
Edna Maria Vissoci ReicheHealth Sciences Post-Graduation Program, Health Sciences Centre, State University of Londrina, Londrina, Brazil.
Sandra Odebrecht Vargas NunesHealth Sciences Post-Graduation Program, Health Sciences Centre, State University of Londrina, Londrina, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Treatment-resistant depression (TRD) is a major clinical challenge, affecting approximately one-third of patients with major depressive disorder (MDD). Genetic factors, particularly genetic variants in the Methods: A systematic literature search was conducted following PRISMA guidelines (PROSPERO registration: CRD42024612628). Studies were included if they investigated Results: Seven studies met the inclusion criteria, and the findings indicate a potential link between Conclusion: While evidence suggests a role for

Indexed as

Genetic polymorphismGenomicsMajor depressive disordersMethylenetetrahydrofolate reductaseTreatment-resistant depression

Identifiers

PMID41737528
PMCPMC12926969

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.