Evidence map›Paper›PMID 41737517›Full record

ArticleFrontiers in surgery2026

Daniel C Freund, Dennis Wahl, Eberhard Grambow, Finn Jaekel, Julia Henne, Richard Kantelberg, Hans Kleemann, Friedrich Prall, Amelie R Zitzmann, Brigitte Vollmar and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Daniel C FreundDepartment of General, Visceral, Thoracic, Vascular and Transplantation Surgery, Rostock University Medical Center, Rostock, Germany.
Dennis WahlDepartment of General, Visceral, Thoracic, Vascular and Transplantation Surgery, Rostock University Medical Center, Rostock, Germany.
Eberhard GrambowDepartment of General, Visceral, Thoracic, Vascular and Transplantation Surgery, Rostock University Medical Center, Rostock, Germany.
Finn JaekelDresden Integrated Center for Applied Physics and Photonic Materials (IAPP), Technical University of Dresden, Dresden, Germany.
Julia HenneDepartment of General, Visceral, Thoracic, Vascular and Transplantation Surgery, Rostock University Medical Center, Rostock, Germany.
Richard KantelbergDresden Integrated Center for Applied Physics and Photonic Materials (IAPP), Technical University of Dresden, Dresden, Germany.
Hans KleemannDresden Integrated Center for Applied Physics and Photonic Materials (IAPP), Technical University of Dresden, Dresden, Germany.
Friedrich PrallInstitute of Pathology, University Medical Center Rostock, Rostock, Germany.
Amelie R ZitzmannDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Medical Centre of Rostock, Rostock, Germany.
Brigitte VollmarRudolf-Zenker-Institute for Experimental Surgery, University Medical Center Rostock, Rostock, Germany.
Jochen HampeDepartment of Medicine I, University Medical Center Dresden, Technische Universität Dresden, Dresden, Germany.
Karl LeoDresden Integrated Center for Applied Physics and Photonic Materials (IAPP), Technical University of Dresden, Dresden, Germany.
Sebastian HinzDepartment of General, Visceral, Thoracic, Vascular and Transplantation Surgery, Rostock University Medical Center, Rostock, Germany.
Clemens SchafmayerDepartment of General, Visceral, Thoracic, Vascular and Transplantation Surgery, Rostock University Medical Center, Rostock, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Anastomotic leakage (AL) represents one of the most serious complications in gastrointestinal surgery, with reported incidence rates of up to 26%. Despite advancements in surgical techniques, early detection of AL remains challenging, and no reliable real-time monitoring system is currently available. In this study, we investigated a resorbable polydioxanone (PDO) membrane as a potential substrate for future sensor integration, aiming to facilitate real-time monitoring of anastomotic healing. Methods: In eight German Landrace pigs, 34 ileal side-to-end stapler anastomoses were examined: GM1 ( Results: Both membrane geometries showed robust stability, with good anchorage of the large spokes within the anastomosis. Geometry 1 (GM1) exhibited higher burst pressure than Geometry 2 (GM2) (193 ± 43.6 vs. 155 ± 65.5 mmHg, Conclusion: This proof-of-concept study demonstrates that the PDO membrane can be safely incorporated into stapled anastomoses without compromising anastomotic healing. The membrane provides a stable, biocompatible platform suitable for future sensor integration, supporting the development of a diagnostic intraanastomotic device.

Indexed as

anastomotic healinganastomotic leakbiodegradablein vivoPDO membraneporcine modelsmall intestine

Identifiers

PMID41737517
PMCPMC12926394

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.