SynthesisFrontiers in medicine2026
Aspirin vs. enoxaparin for thromboprophylaxis after total hip arthroplasty, total knee arthroplasty, or hip fracture surgery-a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Aspirin vs. Low-Molecular-Weight Heparin in Orthopedic Trauma: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Association of prognostic nutritional index with fecal incontinence and fecal incontinence severity index in individuals with osteoporosis: mediating roles of C-reactive protein and gamma-glutamyl transferase.Frontiers in nutrition · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To systematically evaluate the efficacy and safety of aspirin vs. enoxaparin for the prevention of venous thromboembolism (VTE) following major orthopedic surgeries. Methods: We systematically searched PubMed, the Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Wanfang, and CQVIP (VIP) databases from their inception until August 2025 for randomized controlled trials (RCTs) and cohort studies comparing aspirin with enoxaparin for thromboprophylaxis in patients undergoing major orthopedic surgeries (total hip/knee arthroplasty, hip fracture surgery). Two researchers independently performed literature screening, data extraction, and risk-of-bias assessment for the included studies. A meta-analysis was conducted using Review Manager (RevMan) version 5.3 software. Results: A total of studies involving 126,367 patients (43,441 in the aspirin group and 82,926 in the enoxaparin group) were included. Regarding efficacy, the initial meta-analysis showed no significant difference in the incidence of pulmonary embolism (PE; odds ratio [OR] = 1.14, 95% CI: 0.66-1.95) or deep vein thrombosis (DVT; primary analysis: Test for overall effect: Z = 0.43, Conclusion: For patients undergoing major orthopedic surgery, aspirin is comparable to enoxaparin in preventing the primary efficacy outcomes of VTE (pulmonary embolism and deep vein thrombosis) but demonstrates a significant advantage in reducing the risk of minor bleeding. Aspirin represents an effective and safer prophylactic option, particularly for patients with higher bleeding risk profiles.
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Registered trials
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