ArticleFrontiers in medicine2026
Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio as prognostic indicators in
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Objectives: To investigate the prognostic value of dynamic changes in the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) among patients with PJP. Methods: A retrospective study of 165 PJP patients was conducted at two tertiary hospitals. Post-diagnostic trajectories of NLR, MLR, and PLR were analyzed using group-based trajectory modeling (GBTM). Associations between these trajectories and 28-day survival were assessed by Cox proportional hazards regression and Kaplan-Meier survival analysis. Results: Three distinct NLR trajectories were identified: continuously decreasing (15%), stable (68%), and continuously increasing (17%). Patients with continuously decreasing NLR had significantly lower 28-day survival ( Conclusion: The temporal trajectory of logNLR is strongly associated with 28-day survival in PJP. A persistently declining logNLR predicts poor prognosis, suggesting its utility in early risk stratification.
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