ArticleFrontiers in nutrition2026
Association between serum PLP levels and the natural resolution of nausea and vomiting in pregnancy: a secondary analysis.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Vitamin B6 in nausea and vomiting of pregnancy: metabolism, mechanisms, and clinical implications-a narrative review.Frontiers in nutrition · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Nausea and vomiting in pregnancy (NVP) are common clinical symptoms in early gestation. Although vitamin B6 supplementation has been shown to alleviate NVP, the physiological significance of its active form, pyridoxal 5'-phosphate (PLP), and its association with the natural course of symptom resolution remain unclear. Objective: To investigate the association between serum PLP levels in early pregnancy and the natural resolution of NVP, and to elucidate its potential physiological mechanisms to support individualized intervention strategies. Methods: 352 pregnant women with NVP symptoms were enrolled at ≤12 gestational weeks. The exposure variable was serum PLP concentration, categorized into quartiles (Q1-Q4). The primary outcome was the time to spontaneous NVP resolution, defined by a "7-day confirmation criterion." Cumulative remission rates were compared across quartiles using Kaplan-Meier analysis. Multivariate Cox proportional hazards models were constructed with stratified control for treatment arms (A-D), and restricted cubic spline (RCS) functions were applied to examine potential dose-response relationships. Results: Kaplan-Meier analysis revealed significant differences in cumulative remission rates among PLP quartiles (log-rank Conclusion: Higher serum PLP levels in early pregnancy were significantly associated with a faster rate of spontaneous remission of NVP. The observed linear association suggests that the active form of vitamin B6 may regulate NVP progression, reflecting the biochemical basis of natural symptom resolution. PLP may be a potential biomarker for evaluating NVP severity and predicting individualized therapeutic response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.