ReviewJournal of pain research2026
Pulsed Radiofrequency and Epigenetic Modulation of Pain Pathways: A Systematic Review Based on Preclinical Evidence.
Review in Journal of pain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Oxycodone combined with pulsed radiofrequency for refractory cancer pain from spinal metastases: a randomized controlled study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- Early pain-response trajectories after basivertebral nerve ablation and their relationship to 12-month clinical outcomes.Interventional pain medicine · 2026Article
- Interventional Pain Procedures: A Narrative Review Focusing on Safety and Complications. Part 3 - Sympathetic and Ganglion-Targeted Techniques.Journal of pain research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Pulsed radiofrequency (PRF) is used for refractory neuropathic pain, yet its mechanisms remain incompletely defined. The dorsal root ganglion (DRG) and peripheral nerves (eg, sciatic nerve) are common targets and key nodes in nociceptive transmission and neuro-immune crosstalk. Compared with implantable electrical neuromodulation (SCS/PNS), PRF provides non-invasive, percutaneous neuromodulation. Epigenetic regulation after PRF is plausible because chronic pain causes transcriptional modifications and electrical neuromodulation may influence chromatin-based gene control. Objective: To summarize preclinical evidence on epigenetic and molecular changes after PRF applied to the DRG or peripheral nerves. Methods: PubMed, Embase, and Scopus were searched (PRISMA-S); synthesis followed SWiM. Studies assessed direct epigenetic modifications and/or gene/protein expression changes after PRF at DRG or peripheral nerve targets. Risk of bias was evaluated using the JBI checklist for animal studies. Results: Seventeen rodent studies were included. One study reported a direct epigenetic modification, showing that PRF reversed complete Freund's adjuvant (CFA)-induced histone H3/H4 hypoacetylation at the Conclusion: Preclinical data support a non-destructive PRF mechanism involving dampening of neuro-immune signaling and restoration of inhibitory tone. Direct epigenetic evidence remains limited (single study) and absent in humans. Priorities include standardized PRF parameter reporting, time-course and multi-omic profiling beyond
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Registered trials
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