Evidence map›Paper›PMID 41737284›Full record

ArticleBrain communications2026

CSF protein clearance impairment revealed using stable isotope kinetics in normal pressure hydrocephalus.

Claire A Leckey, Tatiana A Giovannucci, Eimear C Murphy, Eleanor M Moncur, Kanza Tariq, Aram Aslanyan, Michael Schöll, Meera Srikrishna, William Coath, Suzanne Barker and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Passing the torch atBrain communications · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Claire A LeckeyDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Tatiana A GiovannucciDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0001-8978-6318
Eimear C MurphyDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Eleanor M MoncurDepartment of Neurosurgery, National Hospital for Neurology and Neurosurgery, University College Hospitals NHS Trust, London WC1N 3BG, UK.
Kanza TariqDepartment of Neurosurgery, National Hospital for Neurology and Neurosurgery, University College Hospitals NHS Trust, London WC1N 3BG, UK.
Aram AslanyanDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0003-3220-6313
Michael SchöllDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0001-7800-1781
Meera SrikrishnaDepartment of Psychiatry and Neurochemistry, University of Gothenburg, Gothenburg 413 45, Sweden.ORCID https://orcid.org/0000-0002-5769-1653
William CoathDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0002-3976-9461
Suzanne BarkerDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Dylan EsguerraDepartment of Neurology, School of Medicine, University of Washington, Seattle WA 98195, USA.
Ahmed K TomaDepartment of Neurosurgery, National Hospital for Neurology and Neurosurgery, University College Hospitals NHS Trust, London WC1N 3BG, UK.
Laurence D WatkinsDepartment of Neurosurgery, National Hospital for Neurology and Neurosurgery, University College Hospitals NHS Trust, London WC1N 3BG, UK.
Lewis ThorneDepartment of Neurosurgery, National Hospital for Neurology and Neurosurgery, University College Hospitals NHS Trust, London WC1N 3BG, UK.
Sylvain LehmannInstitute for Regenerative Medicine and Biotherapy, Institute for Neurosciences of Montpellier, 34090, France.
Jerome VialaretInstitute for Regenerative Medicine and Biotherapy, Institute for Neurosciences of Montpellier, 34090, France.
Selina WrayDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0003-3062-7050
Randall J BatemanDepartment of Neurology, Washington University St Louis, St Louis, MO 63110, USA.ORCID https://orcid.org/0000-0002-7729-1702
Kevin MillsTranslational Mass Spectrometry Research Group, UCL Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
Donald L ElbertDepartment of Neurology, Washington University St Louis, St Louis, MO 63110, USA.
Laura PellegriniCentre for Developmental Neurobiology, Kings College London, London SE1 1UL, UK.
Ross W PatersonDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0001-9372-3635

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Normal pressure hydrocephalus is a common cause of gait and cognitive impairment in older adults, marked by excessive CSF accumulation. Genetic studies suggest impaired fluid clearance, and clinical symptoms can improve after CSF diversion. However, no fluid biomarkers exist to explore CSF accumulation mechanisms, assist diagnosis, or predict response to treatment. Stable isotope labelling kinetics is a clinical research tool that uses non-radioactive isotopes to label newly translated proteins, enabling measurement of their appearance (synthesis) and disappearance (clearance) in compartments like CSF. This study aimed to develop a novel method to capture protein turnover in CSF and assess whether clearance disruption is evident in normal pressure hydrocephalus with extended follow-up. Proteins of interest were identified via mass spectrometry in human CSF and choroid plexus organoid-derived CSF-like fluid. Protein origin and synthesis rates were evaluated by labelling organoids with

Indexed as

cognitivedementianeurosurgery

Identifiers

PMID41737284
PMCPMC12926509

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.