ArticleFrontiers in immunology2026
Follicular helper-like γδ T cells promote plasma cell differentiation in Behçet's disease.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Targeted replacement of human γδ TCR in mice enhances antigen-specific B cell immunity.Frontiers in immunology · 2026Article
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11 authors.
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Abstract
Objectives: Behçet's disease (BD) is a systemic vasculitis characterized by recurrent oral and genital ulcers. The disease can manifest diverse phenotypes -such as mucocutaneous, ocular BD- with an uncertain role for autoantibodies in disease pathogenesis. Altered γδT-cell and B-cell phenotypes have been widely reported in BD, but it remains unknown whether these lineages can interact to promote autoantibody production. Methods: This study included 75 patients with a BD diagnosis, alongside 41 healthy control (HC) volunteers. We performed Results: BD patients with active disease displayed a significant increase in the frequency of cells CXCR5 Conclusion: Our findings suggest that γδT cells may enhance B-cell differentiation into antibody-producing plasma cells in BD patients with mucocutaneous and ocular clinical phenotypes.
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