Evidence map›Paper›PMID 41737220›Full record

ArticleFrontiers in immunology2026

Divergent CD45

Selma Dizdarević, René Wiegandt, Andreas Weigert, Thorsten Stiewe, Bastian Eul, Stefan Guenther, Friedrich Grimminger, Werner Seeger, Soni Savai Pullamsetti, Mario Looso and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Selma DizdarevićInstitute for Lung Health (ILH), Justus-Liebig University, Giessen, Germany.
René WiegandtMax-Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany.
Andreas WeigertDepartment for Immunity of Inflammation, Mannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Thorsten StieweInstitute for Lung Health (ILH), Justus-Liebig University, Giessen, Germany.
Bastian EulDepartment of Internal Medicine, Justus-Liebig University Giessen, Member of the DZL, Member of CPI, Giessen, Germany.
Stefan GuentherMax-Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany.
Friedrich GrimmingerInstitute for Lung Health (ILH), Justus-Liebig University, Giessen, Germany.
Werner SeegerInstitute for Lung Health (ILH), Justus-Liebig University, Giessen, Germany.
Soni Savai PullamsettiInstitute for Lung Health (ILH), Justus-Liebig University, Giessen, Germany.
Mario LoosoMax-Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research (DZL), Member of the Cardio-Pulmonary Institute (CPI), Bad Nauheim, Germany.
Kati TurkowskiInstitute for Lung Health (ILH), Justus-Liebig University, Giessen, Germany.
Rajkumar SavaiInstitute for Lung Health (ILH), Justus-Liebig University, Giessen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The lung tumor microenvironment (TME) plays a crucial role in the progression and metastasis of lung cancer. It consists of various cell types that interact in complex ways to influence tumor behavior. CD45 Methods: We performed single-cell RNA sequencing of sorted CD45 Results: Four major immune compartments, B cells, T cells, NK cells, and macrophages, underwent model-specific remodeling. LLC1 tumors showed B cell expansion and T and NK cell reduction, with inflammatory, stress-response, and NF-κB/TNF-dominant programs. Kras Conclusion: Distinct CD45

Indexed as

Leukocyte Common AntigensLung NeoplasmsTumor MicroenvironmentAnimalsCell Line, TumorHumansLymphocytes, Tumor-InfiltratingMiceSingle-Cell Gene Expression AnalysisT-LymphocytesLeukocyte Common AntigensPtprc protein, mouseCD45+ cellsKrasLA2lung cancersingle-cell RNA sequencingtumor microenvironment

Identifiers

PMID41737220
PMCPMC12926470

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.