Geographic Disparities in the Opioid Overdose Crisis: Access, Treatment, and Mortality.

The opioid overdose crisis in the United States (U.S.) exhibits profound and persistent geographic inequalities, where place of residence is a key determinant of risk, access to care, and mortality. This narrative review synthesizes evidence on the spatial evolution of the epidemic-from its prescription opioid origins in Appalachia to the nationalized spread of illicit fentanyl and polysubstance use-revealing that mortality "hotspots" are direct manifestations of underlying social vulnerability, economic distress, and healthcare infrastructural deficits. We document a severe, multi-layered chasm in access to life-saving medications for opioid use disorder (MOUD), characterized by rural treatment deserts-geographic areas with a critical shortage of MOUD providers-for buprenorphine, structurally embedded barriers to methadone, and restrictive insurance policies. The review further identifies the criminal justice system as a critical risk amplifier, where incarceration and the post-release period represent times of extreme overdose vulnerability due to systemic failures in care continuity. Finally, we examine telehealth as a promising yet precarious tool for expanding access, one that is itself constrained by digital divides and uncertain regulations. The evidence underscores that geographic disparities are not incidental but are produced by an interconnected system of policy, infrastructure, and inequity. Consequently, mitigating the crisis requires moving beyond one-size-fits-all approaches to implement coordinated, place-based strategies that dismantle treatment barriers, integrate harm reduction into justice systems, and ensure equitable access to evidence-based interventions across all communities.