ArticleCureus2026
Dosimetric Discrepancy Between Whole-Lung and Lobe-Specific Metrics in Lung Stereotactic Body Radiotherapy and Its Implications for Regional Dose Assessment.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionStereotactic body radiotherapy (SBRT) is a standard treatment for early-stage non-small cell lung cancer (NSCLC). Radiation pneumonitis is a major dose-limiting toxicity, typically assessed using whole-lung metrics like mean lung dose (MLD) and relative lung volume receiving at least 20 Gy (V
methodsWe retrospectively analyzed 10 patients with T1-T2N0M0 NSCLC treated with SBRT (42 Gy in four fractions). Lung lobes - right upper, middle, lower, and left upper and lower - were automatically segmented using deep learning-based software (OncoStudio; Oncosoft, Seoul, South Korea) and manually refined. The lobe containing the tumor was defined as the tumor-bearing lobe (TBL), while others were defined as non-tumor-bearing lobes (NTBLs). Dose-volume histogram (DVH) parameters (MLD, relative lung volume receiving at least 5 Gy (V
resultsTBL-specific dose intensities were markedly higher than whole-lung metrics: median V
conclusionConventional whole-lung metrics substantially underestimate the radiation concentration within the TBL due to volumetric dilution. While high-dose whole-lung parameters like V
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