Evidence map›Paper›PMID 41737071›Full record

ArticleCureus2026

Ectopic Adrenocorticotropic Hormone (ACTH) Syndrome Caused by Mediastinal Carcinoma: A Report of a Rare Case.

Sara Hassane, Zineb Serhane, Mohammed Amine Essafi, Zineb Elazime, Hayat Aynaou, Houda Salhi

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sara HassaneDepartment of Endocrinology, Diabetology, Metabolic Diseases and Nutrition, Hassan II University Hospital, Fez, MAR.
Zineb SerhaneDepartment of Endocrinology, Diabetology, Metabolic Diseases and Nutrition, Hassan II University Hospital, Fez, MAR.
Mohammed Amine EssafiDepartment of Endocrinology, Diabetology, Metabolic Diseases and Nutrition, Hassan II University Hospital, Fez, MAR.
Zineb ElazimeDepartment of Endocrinology, Diabetology, Metabolic Diseases and Nutrition, Hassan II University Hospital, Fez, MAR.
Hayat AynaouDepartment of Endocrinology, Diabetology, Metabolic Diseases and Nutrition, Hassan II University Hospital, Fez, MAR.
Houda SalhiDepartment of Endocrinology, Diabetology, Metabolic Diseases and Nutrition, Hassan II University Hospital, Fez, MAR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a rare cause of ACTH-dependent Cushing's syndrome, exceptionally due to mediastinal carcinoma. We report a 37-year-old man with Cushingoid features, hypercortisolism, and elevated ACTH. Imaging revealed an unresectable anterior mediastinal mass; biopsy confirmed high-grade neuroendocrine carcinoma. Despite medical therapy and chemoradiotherapy, the outcome was fatal within months. This case highlights the rarity, diagnostic difficulty, and poor prognosis of mediastinal EAS.

Indexed as

acthcushing's syndromeectopicmediastinal carcinomaneuroendocrine tumor

Identifiers

PMID41737071
PMCPMC12926686

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.