Evidence map›Paper›PMID 41737046›Full record

ArticleInternational journal of nanomedicine2026

Glioma Cell Membrane-Coated CaCO

Shiqiang Hou, Chao Zhang, Yu Wang, Xinwei Li, Zihao Wang, Jing Wang, Minfeng Yang, Zhen Liang, Ning Lin

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shiqiang Hou *Department of Neurosurgery, The Affiliated Chuzhou Hospital of Anhui Medical University, The First People's Hospital of Chuzhou, Chuzhou, 239001, People's Republic of China.ORCID 0000-0002-5117-7442
Chao Zhang *Department of Neurosurgery, The Affiliated Chuzhou Hospital of Anhui Medical University, The First People's Hospital of Chuzhou, Chuzhou, 239001, People's Republic of China.
Yu Wang *Department of Neurosurgery, The Affiliated Chuzhou Hospital of Anhui Medical University, The First People's Hospital of Chuzhou, Chuzhou, 239001, People's Republic of China.
Xinwei LiDepartment of Neurosurgery, The Affiliated Chuzhou Hospital of Anhui Medical University, The First People's Hospital of Chuzhou, Chuzhou, 239001, People's Republic of China.ORCID 0009-0005-6578-8454
Zihao WangDepartment of Neurosurgery, The Affiliated Chuzhou Hospital of Anhui Medical University, The First People's Hospital of Chuzhou, Chuzhou, 239001, People's Republic of China.ORCID 0009-0005-9422-1967
Jing WangDepartment of Neurosurgery, The Affiliated Chuzhou Hospital of Anhui Medical University, The First People's Hospital of Chuzhou, Chuzhou, 239001, People's Republic of China.
Minfeng YangSchool of Public Health, Nantong University, Nantong, 226004, People's Republic of China.
Zhen LiangSchool of Biomedical Engineering, Anhui Medical University, Hefei, 230032, People's Republic of China.
Ning LinDepartment of Neurosurgery, The Affiliated Chuzhou Hospital of Anhui Medical University, The First People's Hospital of Chuzhou, Chuzhou, 239001, People's Republic of China.ORCID 0000-0003-0440-4304

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Postoperative recurrence of glioma remains a major clinical challenge due to the blood-brain barrier and an immunosuppressive tumor microenvironment, necessitating innovative local treatment strategies. Methods: We developed a biomimetic nanoplatform (CaDM) by coating doxorubicin (DOX)-loaded calcium carbonate nanoparticles with a glioma cell membrane. This construct was then integrated with the clinical hemostatic agent Surgiflo to create an in-situ forming depot for localized application into the tumor resection cavity. Results: The CaDM nanoparticles exhibited excellent acid-responsive degradation, enabling simultaneous release of DOX and Ca Conclusion: This work presents a readily translatable and multifaceted nanomedicine approach that effectively prevents glioma recurrence through synergistic calcium overload and immunomodulation, offering a promising novel strategy for local tumor treatment.

Indexed as

Brain NeoplasmsCalciumCalcium CarbonateDoxorubicinGliomaNanoparticlesNeoplasm Recurrence, LocalAnimalsCell Line, TumorCell MembraneHumansMiceTumor MicroenvironmentCalciumCalcium CarbonateDoxorubicinCaCO3Calcium overloadGlioma recurrenceImmunogenic cell deathSurgiflo

Identifiers

PMID41737046
PMCPMC12927867

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.