ReviewInternational journal of nanomedicine2026
Novel Carbon Dots Nanomaterials for the Precision Diagnosis and Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome: Mechanisms and Applications.
Review in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Nanozymes as Emerging Therapeutics for Asthma: A Redox-Responsive and Immunomodulatory Strategy.Biomedicines · 2026Review
- Nanomedicine for Acute Respiratory Distress Syndrome: From Pathophysiological Mechanisms and Disease Heterogeneity to Precision Therapy.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute Lung Injury (ALI) and its severe manifestation, Acute Respiratory Distress Syndrome (ARDS), represent critical clinical challenges characterized by diffuse alveolar damage, uncontrolled inflammatory storms, and oxidative stress. Despite supportive therapies such as mechanical ventilation have advanced considerably, mortality rates remain persistently high. Over the past five years, Carbon Dots (CDs)-a novel class of zero-dimensional carbon nanomaterials-have demonstrated significant potential for the precision theranostics of ALI/ARDS due to their ultra-small size (<10 nm), tunable photoluminescence, superior biocompatibility, and intrinsic enzyme-mimicking activities. This review comprehensively synthesizes frontier advancements in CDs applications for pulmonary diseases over the past five years. We systematically elucidate eco-friendly synthesis strategies, surface functionalization (eg, mannose and RGD peptide targeting), and the mechanisms by which CDs function as nanozymes (mimicking SOD, CAT, and POD) to scavenge reactive oxygen species (ROS). Particular emphasis is placed on novel therapeutic strategies, including the modulation of the gut-lung axis to remodel intestinal flora and the construction of ROS-responsive smart drug delivery systems (eg, for siRNA and glucocorticoids). Furthermore, we compare the inhalation toxicology of CDs against traditional carbon materials like carbon nanotubes and evaluate their utility in in vivo lung inflammation imaging and microenvironmental sensing (NO, pH). This review aims to provide a theoretical foundation and strategic direction for the clinical translation of CD-based nanomedicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.