ArticleBeilstein journal of nanotechnology2026
Polycatecholamine nanocoatings on stainless steel: the effect on attachment of human fibroblasts and platelets.
Article in Beilstein journal of nanotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Polydopamine (PDA) is widely used to functionalize materials and enhance cell attachment. At the same time, the potential of the dopamine precursor tyrosine in its polymerized form (polytyrosine, PTYR) remains underexplored despite its biological activity. In this study, we developed nanostructured PDA and PTYR layers on stainless steel 316L via a novel in situ oxidation process and evaluated their physicochemical properties and cellular interactions at the nano/microscale. Surface characterization revealed that the polymeric coatings formed a homogenous layer with distinct topographical features and thickness in the nanometer range for PTYR and in the micrometer range in case of PDA. Compared to PDA, PTYR coatings exhibited a nanoparticulate surface morphology and higher stability under physiological conditions. Wettability, roughness, and amine group density were systematically analyzed to determine their influence on interactions with fibroblasts and platelets. Our results show that PTYR nanocoatings significantly reduced platelet adhesion and activation, whereas PDA coatings, due to their higher primary amine content, could in some cases enhance platelet adhesion. Furthermore, fibroblast attachment was primarily influenced by coating roughness, with a specific threshold beyond which adhesion did not increase or was negatively impacted. These findings highlight the potential of engineered PTYR nanocoatings for developing advanced hemocompatible surfaces for biomedical implants.
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