Evidence map›Paper›PMID 41736998›Full record

ArticleBioinformatics advances2026

REDAC: RNA-seq expression data analysis chatbot.

Giovanni Maria De Filippis, Pranoy Sahu, Pasqualina Ambrosio, Stefania Picascia, Matteo Lo Monte, Ilenia Agliarulo, Simone Di Paola, Cristiano Russo, Christian Tommasino, Nicola Normanno and 4 more

Abstract read
In one paragraph

Article in Bioinformatics advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Giovanni Maria De FilippisDepartment of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, 80125, Italy.
Pranoy SahuConsiglio Nazionale Delle Ricerche, Naples, 80131, Italy.
Pasqualina AmbrosioConsiglio Nazionale Delle Ricerche, Naples, 80131, Italy.
Stefania PicasciaConsiglio Nazionale Delle Ricerche, Naples, 80131, Italy.
Matteo Lo MonteConsiglio Nazionale Delle Ricerche, Naples, 80131, Italy.
Ilenia AgliaruloConsiglio Nazionale Delle Ricerche, Naples, 80131, Italy.
Simone Di PaolaConsiglio Nazionale Delle Ricerche, Naples, 80131, Italy.
Cristiano RussoDepartment of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, 80125, Italy.
Christian TommasinoDepartment of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, 80125, Italy.
Nicola NormannoIRCCS Istituto Romagnolo per lo studio dei Tumori "Dino Amadori" (IRST), Meldola, 47014, Italy.
Daniela FrezzettiCell Biology and Biotherapy Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Naples, 80131, Italy.
Seetharaman ParashuramanConsiglio Nazionale Delle Ricerche, Naples, 80131, Italy.
Antonio M RinaldiDepartment of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, 80125, Italy.
Francesco RussoConsiglio Nazionale Delle Ricerche, Naples, 80131, Italy.ORCID https://orcid.org/0000-0002-7017-8344

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Motivation: To date, due to the complexity of both the analytical processes and the result interpretation of RNA-seq expression data analyses, researchers often require the support of bioinformaticians expertise. Selecting appropriate statistical tests and performing essential data manipulations, such as normalization and filtering, in a rigorous and reproducible manner remains a significant challenge for many users. Results: We developed REDAC, a web-based R application that offers an interactive platform designed to simplify and enhance RNA-seq expression data exploration and analysis. REDAC provides a straightforward approach to perform differentially RNA-seq analysis rapidly, easily, and transparently through natural language queries from users. Moreover, it allows to run complete analyses, generate comprehensive visualizations, and obtain biological interpretation of pathway enrichment results via two popular Large Language Models: Availability and implementation: REDAC is available for local (https://github.com/franruss/REDAC) and online use (https://frusso.shinyapps.io/REDAC). User manual: https://github.com/franruss/REDAC/blob/main/docs/REDAC_user_manual.pdf.

Identifiers

PMID41736998
PMCPMC12927421

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.