ArticleDEN open2026
Immunoglobulin G4-Related Disease-Like Gastric Lesion Presenting as Submucosal Tumor-Like Lesions.
Article in DEN open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Immunoglobulin G4 (IgG4)-related disease (RD) is a systemic fibroinflammatory condition characterized by infiltration of IgG4-positive plasma cells (PCs). Gastrointestinal involvement may present as submucosal tumor-like lesions and poses diagnostic challenges. We report a case of a 59-year-old man with gastric submucosal tumor-like lesions detected during routine screening. Endoscopic submucosal dissection (ESD) was used for the diagnosis and treatment. A histopathological examination revealed abundant IgG4-positive PC infiltration in the submucosa; however, these findings did not fulfill the comprehensive diagnostic criteria for IgG4-RD. IgG4-RD-like gastric lesions can mimic submucosal tumors. ESD may provide diagnostic and therapeutic benefits when a conventional biopsy is insufficient. Cautious interpretation of IgG4-positive PC infiltration in gastrointestinal specimens is required.
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