ArticleiScience2026
Multi-omics and causal inference reveal lactylation-based osteoblast regulatory networks and drug candidates.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Bone loss-related disorders, driven by impaired osteoblast activity, pose a growing global health challenge, yet current anabolic therapies remain limited due to an incomplete understanding of osteoblast dysfunction. Emerging evidence suggests that lactate-derived lysine lactylation-a glycolysis-linked PTM-may regulate osteoblast differentiation and bone homeostasis, though its landscape and functional impact in osteoblasts are largely unknown. Here, we integrated multi-omics profiling, Mendelian randomization (MR), and computational modeling to investigate lactylation-mediated osteogenic regulation. Using
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