Evidence map›Paper›PMID 41736854›Full record

ArticleiScience2026

Spatial transcriptomics reveals the molecular signatures of prodromal and advanced α-synucleinopathy.

Lin Lin, Nanna M Jensen, Alberto Delaidelli, Sara A Ferreira, Fatemeh Yarmahmoudi, Poul H Sorensen, Marina Romero-Ramos, Poul H Jensen, Ian R Mackenzie, Jens R Nyengaard and 1 more

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In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lin LinDepartment of Biomedicine, Aarhus University, Høegh-Guldbergs Gade 10, 8000 Aarhus, Denmark.
Nanna M JensenDepartment of Biomedicine, Aarhus University, Høegh-Guldbergs Gade 10, 8000 Aarhus, Denmark.
Alberto DelaidelliDepartment of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada.
Sara A FerreiraDepartment of Biomedicine, Aarhus University, Høegh-Guldbergs Gade 10, 8000 Aarhus, Denmark.
Fatemeh YarmahmoudiCore Center for Molecular Morphology, Section for Stereology and Microscopy, Department of Clinical Medicine, Aarhus University, Aarhus N, 8200 Aarhus, Denmark.
Poul H SorensenDepartment of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada.
Marina Romero-RamosDepartment of Biomedicine, Aarhus University, Høegh-Guldbergs Gade 10, 8000 Aarhus, Denmark.
Poul H JensenDepartment of Biomedicine, Aarhus University, Høegh-Guldbergs Gade 10, 8000 Aarhus, Denmark.
Ian R MackenzieDepartment of Pathology and Laboratory Medicine, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada.
Jens R NyengaardCore Center for Molecular Morphology, Section for Stereology and Microscopy, Department of Clinical Medicine, Aarhus University, Aarhus N, 8200 Aarhus, Denmark.
Asad JanCore Center for Molecular Morphology, Section for Stereology and Microscopy, Department of Clinical Medicine, Aarhus University, Aarhus N, 8200 Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A pathological role of α-synuclein (aSyn) aggregation in the etiology of Parkinson disease (PD) is well established. Here, we applied spatial transcriptomics (ST) on brain sections derived from a rodent mouse model of α-synucleinopathy (transgenic M83

Indexed as

Model organismMolecular neuroscienceProtein structure aspectsTranscriptomics

Identifiers

PMID41736854
PMCPMC12927100

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.