Evidence map›Paper›PMID 41736794›Full record

ArticleFrontiers in cellular and infection microbiology2026

An integrative ultrastructural and transcriptomic analysis of host-pathogen interactions with human brain microvascular endothelial cells during cryptococcal infection: a preliminary study.

Priya Krishnan, Gautham Arunachal Udupi, Rashmi Santhoshkumar, Manjunatha M V, Veena Kumari H B, Netravathi, Nagarathna S

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Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Priya KrishnanDept of Neuromicrobiology, National Institute of Mental Health and Neuro Sciences, Institute of National Importance, Bengaluru, India.
Gautham Arunachal UdupiDept of Human Genetics, National Institute of Mental Health and Neuro Sciences, Institute of National Importance, Bengaluru, India.
Rashmi SanthoshkumarDept of Neuropathology, National Institute of Mental Health and Neuro Sciences, Institute of National Importance, Bengaluru, India.
Manjunatha M VDept of Neurovirology, National Institute of Mental Health and Neuro Sciences, Institute of National Importance, Bengaluru, India.
Veena Kumari H BDept of Neuromicrobiology, National Institute of Mental Health and Neuro Sciences, Institute of National Importance, Bengaluru, India.
NetravathiDept of Neurology, National Institute of Mental Health and Neuro Sciences, Institute of National Importance, Bengaluru, India.
Nagarathna SDept of Neuromicrobiology, National Institute of Mental Health and Neuro Sciences, Institute of National Importance, Bengaluru, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In humans, Objective: This study aimed to investigate the cyto-morphological and transcriptomic responses of HBMECs to infection by clinical and environmental Methods: HBMECs were infected Results: TEM revealed extensive ultrastructural changes in infected HBMECs, including membrane ruffling, increased microvilli, mitochondrial alterations, ER dilation, Golgi fragmentation, nuclear deformation, and autophagosome formation. Transcriptomic profiling demonstrated functional enrichment of several critical cryptococcal virulence-associated genes linked to immune evasion and stress adaptation including various immune signaling pathways elicited by the HBMECs as a counter measure to the cryptococcal invasion. Conclusion: Clinical and environmental

Indexed as

BrainCryptococcosisCryptococcus gattiiCryptococcus neoformansEndothelial CellsHost-Pathogen InteractionsBlood-Brain BarrierGene Expression ProfilingHumansMicroscopy, Electron, TransmissionTranscriptomeblood-brain barriercryptococcal meningitisdifferential gene expressiondual RNAseqHBMECshost-pathogen interactioninvasiontransmission electron microscopy

Identifiers

PMID41736794
PMCPMC12926436

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.