Evidence map›Paper›PMID 41736719›Full record

ArticleAdvanced functional materials2026

MPI-Guided Photothermal Therapy of Prostate Cancer Using Stem Cell Delivery of Magnetotheranostic Nanoflowers.

Behnaz Ghaemi, Ana Rosu, Shreyas Kuddannaya, Gautier Laurent, Rana Bazzi, Stéphane Roux, Ali Shakeri-Zadeh, Jeff W M Bulte

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Behnaz GhaemiThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-2220-0428
Ana RosuThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Shreyas KuddannayaThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Gautier LaurentUniversité Marie et Louis Pasteur, CNRS, Chrono-environnement (UMR 6249), Besançon, France.ORCID 0000-0002-8544-1379
Rana BazziUniversité Marie et Louis Pasteur, CNRS, Chrono-environnement (UMR 6249), Besançon, France.ORCID 0000-0001-7274-6694
Stéphane RouxUniversité Marie et Louis Pasteur, CNRS, Chrono-environnement (UMR 6249), Besançon, France.ORCID 0000-0002-5198-1916
Ali Shakeri-ZadehThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jeff W M BulteThe Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-1202-1610

Funding

Training/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MARTIN G POMPER · 2017 to 2026
$11.8M
Precision magnetic hyperthermia by integrating magnetic particle imagingR01CA257557 · NCI · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W., IVKOV, ROBERT · 2021 to 2025
$3.2M
Intracellular Self-Assembly of Theranostic Nanoparticles for Enhanced Imaging and Tumor TherapyR01EB030376 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2020 to 2024
$2.1M
Non-Invasive Tracking of Genome-Corrected iPS cells in ALSUH3EB028904 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2021 to 2022
$950k
Magnetic Particle Imaging ScannerS10OD026740 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI BULTE, JEFF W. · 2019 to 2019
$600k
Combined Optical/Micro-CT ScannerS10OD010744 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI BULTE, JEFF W. · 2012 to 2012
$599k
Non-Invasive Tracking of Genome-Corrected iPS cells in ALSUH2EB028904 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2019 to 2020
$482k
NCI NIH HHS R01 CA257557NIBIB NIH HHS P41 EB024495NIBIB NIH HHS R01 EB030376NIBIB NIH HHS UH2 EB028904NIBIB NIH HHS UH3 EB028904NIH HHS S10 OD010744NIH HHS S10 OD026740
6 · The paper itself

Abstract

The efficacy of photothermal therapy (PTT) of cancer critically depends on widespread nanoparticle (NP) distribution and retention within the tumor. However, intratumoral (i.t.) injection of naked NPs may result in poor dispersion and backflow resulting in leakage and rapid clearance, limiting therapeutic outcome and increasing off-target toxicity. To overcome these limitations, we employed tumor-tropic human mesenchymal stem cells (hMSCs) as delivery vehicles for magnetotheranostic gold-iron oxide nanoflowers (GIONF), enabling widespread i.t. distribution and sustained retention in contrast to injection of naked GIONF. GIONF-hMSCs demonstrated superior heating performance under near-infrared laser irradiation while exhibiting a strong magnetic particle imaging (MPI) signal, allowing for noninvasive quantitative tracking of their whole body biodistribution. Laser irradiation at peak GIONF-hMSC retention resulted in complete tumor ablation without recurrence up to 90 days post-treatment. These results are a first demonstration of using MPI to evaluate the retention and leakage of i.t.-injected intracellular versus naked nanoparticles for advancing PTT with cellular magnetotheranostics.

Indexed as

magnetic particle imagingmesenchymal stem cellphotothermal therapyprostate cancertheranostic nanoparticle

Identifiers

PMID41736719
PMCPMC12928986

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.