Evidence map›Paper›PMID 41736703›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

An Implantable Scaffold Sequentially Releasing STING Agonist and B7-H3 Antibody for Bone Metastasis Immunotherapy.

Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qijun LinDepartment of Orthopedic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Hong XiaoDepartment of Medical Ultrasound, Laboratory of Novel Optoacoustic (Ultrasonic) Imaging, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Shuai FanDepartment of Orthopedic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Kaimin CaiDepartment of Medical Ultrasound, Laboratory of Novel Optoacoustic (Ultrasonic) Imaging, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yanteng XuLaboratory of Biomaterials and Translational Medicine, Center For Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Xinwen WangDepartment of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Guanhong ChenDepartment of Orthopedic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Chuandong LangDepartment of Orthopedics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Xinsheng PengDepartment of Orthopedic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Mingqiang LiLaboratory of Biomaterials and Translational Medicine, Center For Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.ORCID https://orcid.org/0000-0002-5178-4138
Yuhu DaiDepartment of Orthopedic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515011580Basic and Applied Basic Research Foundation of Guangdong Province 2024A1515010716Basic and Applied Basic Research Foundation of Guangdong Province 2024A1515030230Basic and Applied Basic Research Foundation of Guangdong Province 2025A1515011186National Natural Science Foundation of China 52373166National Natural Science Foundation of China 52422318National Natural Science Foundation of China 82203721National Natural Science Foundation of China 82302360National Natural Science Foundation of China 82373020National Natural Science Foundation of China 82573230Natural Science Foundation of Guangdong Province for Distinguished Young Scholar 2024B1515020025Natural Science Research Project of Anhui Provincial Department of Education 2023AH053409Science and Technology Program of Guangzhou 2024A04J6572
6 · The paper itself

Abstract

Immune checkpoint blockade (ICB) therapy has revolutionized cancer treatment, yet it remains largely ineffective against bone metastases. The immunosuppressive bone marrow microenvironment is a major barrier to ICB success in bone metastasis. Herein, we developed an implantable dual-drug depot using a gelatin methacryloyl (GelMA) scaffold to prevent tumor recurrence and progression following surgical resection. The GelMA scaffold is co-loaded with MSA-2, a non-nucleotide agonist of stimulator of interferon genes (STING), and calcium carbonate (CaCO

Indexed as

B7 AntigensBone NeoplasmsImmunotherapyMembrane ProteinsAnimalscGAS-STING Signaling PathwayFemaleHumansMiceSTING ProteinTumor MicroenvironmentB7 AntigensCD276 protein, humanMembrane ProteinsSTING ProteinB7‐H3bone metastasiscontrolled releaseimmunotherapyMSA‐2postoperative treatment

Identifiers

PMID41736703
PMCPMC13271628

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.