Evidence map›Paper›PMID 41736425›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026

Alleviation of nitroglycerin-induced migraine in rats: inhibition of central sensitization by optimizing Qinggan Jieyu decoction regulation of purinergic receptor P2X ligand-gated ion channel 7 and autophagy.

L I Jiazheng, Zhou Bo

Abstract read
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

L I JiazhengDepartment of Neurology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China.
Zhou BoDepartment of Neurology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China.

Funding

China Academy of Chinese Medical Sciences Innovation Fund:Multicenter Randomized Controlled Study on the Intervention of Yiqi Huoxue Huatan Tongluo decoction in Post-Stent Restenosis of Vertebral Arteries CI2021A01308In-Hospital Mentorship Program of Xiyuan Hospital, China Academy of Chinese Medical Sciences-Zhou Shaohua 0203055
6 · The paper itself

Abstract

objectiveTo investigate the effects of optimizing Qinggan Jieyu decoction on purinergic receptor P2X ligand-gated ion channel 7 (P2X7R) and autophagy in migraine model rats based on molecular biology and histopathology.

methodsA migraine rat model was established by a single subcutaneous nitroglycerin (NTG) injection into the posterior neck. QGJY was administered

resultsQGJY significantly reduced cage-climbing and head-scratching frequencies in NTG-induced migraine rats, downregulated serum and TNC levels of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha, and suppressed central sensitization markers (substance P; calcitonin gene-related peptide; and c-fos induced growth factor) in TNC tissues (

conclusionsQGJY alleviates migraine and inhibits central sensitization in rats, potentially by downregulating P2X7R expression, concomitantly suppressing autophagy, attenuating microglial activation, and reducing pro-inflammatory cytokine release.

Indexed as

AutophagyDrugs, Chinese HerbalMigraine DisordersReceptors, Purinergic P2X7AnimalsHumansMaleNitroglycerinRatsRats, Sprague-DawleyDrugs, Chinese HerbalNitroglycerinReceptors, Purinergic P2X7autophagymigraine disordersoptimizing Qinggan Jieyu decoctionreceptors, purinergic P2X7

Identifiers

PMID41736425
PMCPMC12884482

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.