ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026
Alleviation of nitroglycerin-induced migraine in rats: inhibition of central sensitization by optimizing Qinggan Jieyu decoction regulation of purinergic receptor P2X ligand-gated ion channel 7 and autophagy.
Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the effects of optimizing Qinggan Jieyu decoction on purinergic receptor P2X ligand-gated ion channel 7 (P2X7R) and autophagy in migraine model rats based on molecular biology and histopathology.
methodsA migraine rat model was established by a single subcutaneous nitroglycerin (NTG) injection into the posterior neck. QGJY was administered
resultsQGJY significantly reduced cage-climbing and head-scratching frequencies in NTG-induced migraine rats, downregulated serum and TNC levels of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha, and suppressed central sensitization markers (substance P; calcitonin gene-related peptide; and c-fos induced growth factor) in TNC tissues (
conclusionsQGJY alleviates migraine and inhibits central sensitization in rats, potentially by downregulating P2X7R expression, concomitantly suppressing autophagy, attenuating microglial activation, and reducing pro-inflammatory cytokine release.
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