ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026
Gegen Qinlian decoction ameliorates experimental colitis in miceferroptosis pathway.
Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveTo explore whether Gegen Qinlian decoction (, GQD) targets ferroptosis pathway to ameliorate experimental colitis in mice.
methodsA mice model of dextran sulfate sodium (DSS) induced colitis was established and therapeutic effects of GQD were determined by detecting body weight, disease activity index (DAI), colon length and histopathological changes. Then, the expression levels of inflammatory cytokines were detected by enzyme-linked immunosorbent assay, the expression levels of tight junction proteins were detected by immunohistochemistry and the expression levels of ferroptosis-associated proteins were detected by western blotting.
resultsGQD treatment attenuated weight loss and DAI score, increased colon length, ameliorated intestinal histopathological damage, inhibited colonic inflammatory cytokine release and enhanced epithelial barrier function in mice with ulcerative colitis (UC). Furthermore, GQD administration obviously improved the expression of ferroptosis-associated proteins (solute carrier family 7 member 11 and acyl-CoA synthetase long chain family member 4).
conclusionGQD could exert a therapeutic effect on colitis by alleviating colon damage and promoting intestinal mucosal barrier repair in DSS-induced colitis mice through the inhibition of ferroptosis, which may provide an effective natural therapy for the treatment of UC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.