Evidence map›Paper›PMID 41736418›Full record

SynthesisJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026

Efficacy of Tongxie Yaofang compared with pinaverium bromide on irritable bowel syndrome with liver depression and spleen deficiency: a systematic review and Meta-analysis.

Zhou Mi, B U Huaien, Wang Dongjun, Zhang Naijin, Sun Xuan, Tian Zhikui, Wang Hongwu

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhou MiSchool of Health Science and Engineering, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
B U HuaienSchool of Health Science and Engineering, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Wang DongjunCollege of Traditional Chinese Medicine, North China University of Science and Technology, Tangshan 063000, China.
Zhang NaijinSchool of Health Science and Engineering, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Sun XuanSchool of Health Science and Engineering, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Tian ZhikuiSchool of Health Science and Engineering, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Wang HongwuSchool of Health Science and Engineering, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.

Funding

National Key Basic Research and Development Plan 973 PlanResearch on Traditional Chinese Medicine Original Thinking and Health State Identification Method System 2011CB505406
6 · The paper itself

Abstract

objectiveTo compare the efficacy of Tongxie Yaofang (, TXYF) versus pinaverium bromide for the treatment of diarrheal irritable bowel syndrome (IBS-D) with liver depression and spleen deficiency.

methodsA search of the China National Knowledge Infrastructure Database, China Science and Technology Journal Database, Wanfang Database, PubMed, EMBASE, Cochrane Library and Web of Science databases was conducted from database creation to the 28th of September 2022. Meta-analysis was performed using Revman 5.4 software.

resultsTwelve randomized controlled trials comprising 1058 patients were included in the analysis. TXYF was more efficacious in improving the clinical symptoms of patients. Comparison of the efficacy rate, Traditional Chinese Medicine Evidence Score (TCM-PES), self-rating anxiety scale anxiety score, self-rating depression scale depression score, adverse reaction rate and calcitonin gene-related peptide (CGRP) levels showed that TXYF was significantly superior to pinaverium bromide treatment (

conclusionsAlthough the results of this study suggest that TXYF may be superior for the treatment of IBS-D with liver depression and spleen deficiency, as compared to pinaverium bromide, definitive conclusions are unable to be drawn at this time due to flaws in the overall design of the included trials. Therefore, more rigorous trials are needed to determine the benefit and safety of TXYF.

Indexed as

Drugs, Chinese HerbalIrritable Bowel SyndromeLiverSpleenDepressionHumansMorpholinesRandomized Controlled Trials as TopicTreatment OutcomeDrugs, Chinese HerbalMorpholinespinaveriumtongxie-yaofangdiarrhea pinaverium bromideirritable bowel syndromeliver depressionspleen deficiencyTongxie Yaofang

Identifiers

PMID41736418
PMCPMC12884499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.