Evidence map›Paper›PMID 41736299›Full record

ArticleActa oncologica (Stockholm, Sweden)2026

The Stockholm Pilot study for Lung cancer Screening (Stockholm PLUS): feasibility of baseline low-dose CT lung cancer screening in a high-risk Swedish female population.

Oscar Grundberg, Paulina Kalinowska, Pierre Hillegren, Nicolas Peyrard Janvid, Axel Dimberg, Nina Markholm Nordgren, Fredrik Strand, Vitali Grozman, Gunnar Wagenius

Abstract read
In one paragraph

Article in Acta oncologica (Stockholm, Sweden), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Oscar GrundbergThoracic Oncology Center, Karolinska University Hospital, Stockholm, Sweden; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-9405-9844
Paulina KalinowskaDepartment of Radiology, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-5285-2200
Pierre HillegrenDepartment of Nuclear Medicine and Medical Physics, Karolinska University Hospital, Stockholm, Sweden.ORCID 0009-0009-1821-6217
Nicolas Peyrard JanvidDepartment of Radiology, Karolinska University Hospital, Stockholm, Sweden.ORCID 0009-0008-8839-4919
Axel DimbergDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Cardiothoracic Surgery, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-6748-5140
Nina Markholm NordgrenRegional Cancer Centers in Sweden, Stockholm, Sweden.
Fredrik StrandDepartment of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden; Department of Radiology, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0003-3910-7086
Vitali GrozmanDepartment of Radiology, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. itali.grozman@ki.se.ORCID 0009-0002-4630-2832
Gunnar WageniusThoracic Oncology Center, Karolinska University Hospital, Stockholm, Sweden; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeLow-dose CT screening of high-risk groups has been shown to reduce lung cancer mortality, and the European Council has therefore recommended that member states explore the feasibility and effectiveness of this approach. In this study, we evaluate the implementation of low-dose CT screening for lung cancer in a Swedish female population. Patient/material and methods: Women aged 54-74 years in the Southern Stockholm region were contacted via an electronic questionnaire. Individuals who met the same eligibility criteria as in the NELSON trial (a minimum smoking history of 15 pack-years) were invited. The screening consisted of a baseline low-dose computed tomography (LDCT) scan, with the option for a follow-up scan in cases with intermediate findings. Findings were managed in accordance with modified Fleischner Society guidelines.

resultsBetween September 2022 and September 2024, 34,580 invitation letters were sent to randomly selected women aged 54-74 years 11,607 individuals (33.4%) completed the questionnaire, whereof 1,106 (10%) met the inclusion criteria. 990 (90%) individuals accepted the invitation and underwent a baseline low-dose CT scan. There were 152 intermediate and 55 positive scans at baseline, and additional eight positive scans at follow-up. Fifteen cases of Lung cancer were found, yielding a positive prediction value (PPV) of 24%. 87% of the lung cancers were in stage IA.

interpretationOrganized lung cancer screening in a Swedish female population proved feasible, demonstrating a good participation rate, and a cancer detection rate consistent with findings from other major screening trials.

Indexed as

Early Detection of CancerLung NeoplasmsTomography, X-Ray ComputedAgedFeasibility StudiesFemaleHumansMass ScreeningMiddle AgedPilot ProjectsRadiation DosageRisk FactorsSurveys and QuestionnairesSweden

Identifiers

PMID41736299
PMCPMC12946860

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.