ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Topography and cognitive impact of brain iron deposition in cerebral amyloid angiopathy: Evidence from 7T quantitative susceptibility mapping.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Early identification of vascular cognitive impairment from a multimodal perspective: a combined diagnosis from targeted cognitive assessments, imaging biomarkers, and molecular fluid biomarkers to ecological behavioral characteristics.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
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8 authors.
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Abstract
introductionWhile brain iron accumulation has been linked to cognitive impairment in aging and small vessel diseases, its spatial pattern and clinical significance in cerebral amyloid angiopathy (CAA) remain poorly defined.
methodsQuantitative susceptibility mapping (QSM) was used to assess region-specific iron deposition across cortical, subcortical, and limbic areas. Associations with conventional cerebral small vessel disease (CSVD) markers-white matter hyperintensities (WMHs), perivascular spaces (PVS), cerebral microbleeds (CMBs), and cortical superficial siderosis (cSS)-were analyzed. A composite Iron Deposition Index (IDI) was generated.
resultsCortical iron correlated with WMH burden, while PVS was positively associated with deep gray matter iron but negatively associated with cortical iron deposition. The IDI was independently associated with global cognition and memory. Combined cortical and deep iron burden explained cognitive outcomes better than traditional CSVD markers. DISCUSSION: QSM demonstrates distinct cortical iron accumulation in CAA, providing correlational evidence with potential implications for understanding vascular cognitive impairment.
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