ArticleInternational journal of cancer2026
The mediating role of the kynurenine pathway in longitudinal associations between dietary intake and quality of life in colorectal cancer survivors up to 12 months posttreatment.
Article in International journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Activity profiles and their correlates in patients with localised renal and colorectal cancer shortly after treatment: a cross-sectional analysis.Journal of cancer survivorship : research and practice · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
Previous research has revealed associations between diet and health-related quality of life (HRQoL), between diet and kynurenine pathway (KP) metabolites (kynurenines), and between kynurenines and HRQoL in colorectal cancer (CRC) survivors. We examined if kynurenines mediate longitudinal associations between diet and HRQoL in CRC survivors up to 12-months posttreatment. Repeated measurements were performed in 209 stage I-III CRC survivors. Diet was assessed by seven-day dietary records. Plasma kynurenines were analyzed using LC-MS/MS. HRQoL outcomes were assessed through the validated EORTC QLQ-C30. We used confounder-adjusted multilevel parallel-multiple mediator models with all kynurenines simultaneously and single mediator models with established KP ratios to estimate total (c:diet-HRQoL), direct (c':diet-HRQoL), metabolite-specific indirect (ab: diet-metabolite-HRQoL), and total indirect (ab:diet-metabolites-HRQoL) effects. Higher carbohydrate intake was associated with worse role functioning, while higher fiber, alcohol, and zinc intake, and better adherence to the Dutch Healthy Diet (DHD) recommendations were associated with better physical and role functioning (c-path). Associations of fiber and DHD with HRQoL remained statistically significant after controlling for all KP metabolites (c'-path). All kynurenines simultaneously only mediated associations of higher carbohydrate intake with worse role functioning, and of higher alcohol intake with better physical functioning (ab). The kynurenic acid-to-quinolinic acid (KA/QA) ratio and hydroxykynurenine ratio (HKr) significantly mediated associations of carbohydrate, protein, fat, alcohol, magnesium, and zinc intake, and adherence to DHD recommendations, with physical and role functioning (ab). In conclusion, while all kynurenines simultaneously did not mediate diet-HRQoL associations, the KA/QA ratio and HKr did mediate several associations within the first year after CRC treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.